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• W2023797283 abstract "Abstract Phospholipid liquid crystals and related (vesicular) structures were prepared from naturally occurring, purified phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidic acid, and phosphatidylinositol, and various mixtures of these compounds, swollen in aqueous salt solutions. The structural characteristics of the above particles prepared by various methods were investigated by optical, electron microscopy and X-ray diffraction methods. Large myelinic figures, as well as small vesicle-type particles, were observed. The size and shape of the particles as well as the degree of birefringence and the extent to which negative stain penetrates between the lamellae during electron microscopy were characteristic of the various phospholipid species used. Phosphatidylethanolamine was exceptional in its tendency to form aggregated particles of high ‘porosity’ in isotomic salt solutions. X-ray diffraction showed the presence of multi-lamellar structures with repeating distances varying from 54 A for phosphatidylethanolamine, to 75 A for phosphatidylserine and 125 A for phosphatidylserine-cytochrome c complex. Ultrasonication produced small (approx. 500 A diameter) sac-like vesicles. Similar structures were formed without sonication, from phosphatidylcholine and phosphatidylcholine-phosphatidylethanolamine mixtures, when a small amount of cytochrome c or albumin were present. The above structural characteristics are discussed in terms of the permeability properties in the following article." @default.
• W2023797283 created "2016-06-24" @default.
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• W2023797283 date "1967-09-01" @default.
• W2023797283 modified "2023-10-18" @default.
• W2023797283 title "Phospholipid model membranes. I. Structural characteristics of hydrated liquid crystals" @default.
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• W2023797283 doi "https://doi.org/10.1016/0005-2736(67)90094-6" @default.
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