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- W2023799258 abstract "Geisler JP, Geisler HE, Wiemann MC, Zhou Z, Miller GA, Crabtree W. MIB-1: A predictor of survival in patients with ovarian carcinoma. Int J Gynecol Cancer 1998; 8: 392–396.Objective: MIB-1, a monoclonal antibody, reacts with the Ki-67 antigen, functioning as a marker of proliferation index. This study was carried out to determine whether MIB-1 staining, using image analysis, was a prognostic indicator in patients with ovarian carcinoma.Methods: The tumors from 93 consecutive patients receiving primary surgical therapy for ovarian cancer were evaluated with MIB-1. Staining was quantified by image analysis. The patients were followed for a mean of 41 months (median, 37 months; minimum, 27 months; maximum, 68 months). Their charts were reviewed to determine survival, histologic type, grade, stage, and level of cytoreduction.Results: Seventy-three patients had serous carcinomas, eight clear cell carcinomas, four endometrioid carcinomas, four mucinous carcinomas, two transitional carcinomas, and two undifferentiated carcinomas. Sixteen patients had stage I disease, four patients had stage II disease, 53 patients had stage III disease, and 20 patients had stage IV disease. Thirty-nine patients died within the observation period of the study. The MIB-1 staining of those patients alive at the conclusion of the study (28.3%) was significantly less than the MIB-1 staining of those who died (42.6%) (P < 0.001). No patient whose tumor had MIB-1 staining of less than 22.0% died during the observation period of the study. MIB-1 staining less than 22.0% (P= 0.020), FIGO stage (P= 0.025), and the level of cytoreduction (P= 0.0006) were independent predictors of survival.Conclusion: In this series of 93 patients with ovarian carcinoma, MIB-1 monoclonal antibody staining was shown to be an independent prognostic indicator of survival. No patient whose tumor stained less than 22% positive nuclear area for MIB-1 died of her ovarian carcinoma." @default.
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- W2023799258 date "1998-09-01" @default.
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- W2023799258 title "MIB-1: a predictor of survival in patients with ovarian carcinoma" @default.
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- W2023799258 doi "https://doi.org/10.1046/j.1525-1438.1998.09866.x" @default.
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