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- W2023922718 abstract "Novel vitamin D receptor (VDR) antagonists, la-hydroxy-24-phenylvitamin D 3 -26,23-lactones were synthesized by Trost's methodology. The biological evaluation revealed that both the binding affinity for VDR and antagonistic activity were affected by the orientation of the phenyl group on the lactone ring. The modification of the 2a-position of the 24-phenylvitamin D 3 lactones improved the antagonistic activity up to 41 times higher than that of TEI-9647." @default.
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- W2023922718 date "2006-01-01" @default.
- W2023922718 modified "2023-09-26" @default.
- W2023922718 title "Synthesis and 2a-Modification of 24-Phenylvitamin D3 Lactones: Effects on VDR Antagonistic Activity" @default.
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- W2023922718 doi "https://doi.org/10.3987/com-05-s(t)32" @default.
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