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- W2024454762 abstract "P6 has been a vaccine candidate for nontypable Haemophilus influenzae (NTHi) based on its location on the outer membrane and immunogenicity. Because P6 is attached to the inner peptidoglycan layer of NTHi, and is putatively surface exposed, it must be a transmembrane protein. We examined the P6 structure using computational modeling, site-directed mutagenesis, and nuclear magnetic resonance spectroscopy. We found that P6 cannot be a transmembrane protein, and therefore may not be surface exposed. We conclude that there may be another protein on the surface of NTHi that has epitopes similar if not identical to P6." @default.
- W2024454762 created "2016-06-24" @default.
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- W2024454762 date "2011-02-01" @default.
- W2024454762 modified "2023-09-28" @default.
- W2024454762 title "Vaccine candidate P6 of nontypable Haemophilus influenzae is not a transmembrane protein based on protein structural analysis" @default.
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- W2024454762 doi "https://doi.org/10.1016/j.vaccine.2010.12.082" @default.
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