Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024951818> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2024951818 endingPage "1144" @default.
- W2024951818 startingPage "1142" @default.
- W2024951818 abstract "This study assessed whether treatment with oral prednisone (bolus plus tapered doses) is comparable to intravenous methylprednisolone sodium succinate (Solu-Medrol) therapy in patients with asymptomatic moderate cardiac allograft rejection episodes without hemodynamic compromise.Intravenous Solu-Medrol therapy is frequently administered for moderate rejection episodes after heart transplantation but has not previously been compared with an oral prednisone therapy for asymptomatic cardiac rejection in a randomized trial. Compared with oral prednisone therapy, the administration of intravenous Solu-Medrol is more costly and resource intensive, and it can require loss of work time for patients and the family members who accompany them to treatment.Forty-one heart transplant patients with 43 episodes of asymptomatic moderate cardiac rejection were randomized to receive 3 days of 1,000 mg of intravenous Solu-Medrol (20 episodes) or prednisone as a bolus dose of 100 mg orally for 3 days, tapering to the previous maintenance dosage over 14 days (23 episodes). Follow-up endomyocardial biopsies were performed at 2 and 4 weeks. Infectious complications were monitored and the cost of the two forms of therapy was assessed.Resolution of moderate rejection occurred within 4 weeks in 19 (95%) of 20 patients treated with intravenous steroids and in 21 (91%) of 23 patients treated with oral prednisone. No significant difference in infectious complications occurred between the two groups in the ensuing 3 months after therapy. The cost of the oral prednisone therapy was $6.30 compared with the cost of $180 to $966 for administration of intravenous Solu-Medrol.Oral prednisone (bolus plus tapered doses) appears to be as effective and to have similar infectious complication rates as intravenous Solu-Medrol for the treatment of asymptomatic cardiac rejection. The convenience and lower cost of oral prednisone therapy may warrant its routine use for this type of cardiac rejection." @default.
- W2024951818 created "2016-06-24" @default.
- W2024951818 creator A5011114824 @default.
- W2024951818 creator A5035769573 @default.
- W2024951818 creator A5054626427 @default.
- W2024951818 creator A5069083851 @default.
- W2024951818 creator A5071437084 @default.
- W2024951818 creator A5087709436 @default.
- W2024951818 creator A5088124461 @default.
- W2024951818 date "1993-04-01" @default.
- W2024951818 modified "2023-09-25" @default.
- W2024951818 title "Is intravenous glucocorticoid therapy better than an oral regimen for asymptomatic cardiac rejection? A randomized trial" @default.
- W2024951818 cites W2017894748 @default.
- W2024951818 doi "https://doi.org/10.1016/0735-1097(93)90237-u" @default.
- W2024951818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8459068" @default.
- W2024951818 hasPublicationYear "1993" @default.
- W2024951818 type Work @default.
- W2024951818 sameAs 2024951818 @default.
- W2024951818 citedByCount "26" @default.
- W2024951818 countsByYear W20249518182012 @default.
- W2024951818 countsByYear W20249518182014 @default.
- W2024951818 countsByYear W20249518182018 @default.
- W2024951818 countsByYear W20249518182019 @default.
- W2024951818 countsByYear W20249518182020 @default.
- W2024951818 countsByYear W20249518182021 @default.
- W2024951818 crossrefType "journal-article" @default.
- W2024951818 hasAuthorship W2024951818A5011114824 @default.
- W2024951818 hasAuthorship W2024951818A5035769573 @default.
- W2024951818 hasAuthorship W2024951818A5054626427 @default.
- W2024951818 hasAuthorship W2024951818A5069083851 @default.
- W2024951818 hasAuthorship W2024951818A5071437084 @default.
- W2024951818 hasAuthorship W2024951818A5087709436 @default.
- W2024951818 hasAuthorship W2024951818A5088124461 @default.
- W2024951818 hasConcept C141071460 @default.
- W2024951818 hasConcept C168563851 @default.
- W2024951818 hasConcept C2777910003 @default.
- W2024951818 hasConcept C2778720950 @default.
- W2024951818 hasConcept C2778849806 @default.
- W2024951818 hasConcept C2780372218 @default.
- W2024951818 hasConcept C2780608335 @default.
- W2024951818 hasConcept C2781413609 @default.
- W2024951818 hasConcept C2911091166 @default.
- W2024951818 hasConcept C42219234 @default.
- W2024951818 hasConcept C43376680 @default.
- W2024951818 hasConcept C71924100 @default.
- W2024951818 hasConceptScore W2024951818C141071460 @default.
- W2024951818 hasConceptScore W2024951818C168563851 @default.
- W2024951818 hasConceptScore W2024951818C2777910003 @default.
- W2024951818 hasConceptScore W2024951818C2778720950 @default.
- W2024951818 hasConceptScore W2024951818C2778849806 @default.
- W2024951818 hasConceptScore W2024951818C2780372218 @default.
- W2024951818 hasConceptScore W2024951818C2780608335 @default.
- W2024951818 hasConceptScore W2024951818C2781413609 @default.
- W2024951818 hasConceptScore W2024951818C2911091166 @default.
- W2024951818 hasConceptScore W2024951818C42219234 @default.
- W2024951818 hasConceptScore W2024951818C43376680 @default.
- W2024951818 hasConceptScore W2024951818C71924100 @default.
- W2024951818 hasIssue "5" @default.
- W2024951818 hasLocation W20249518181 @default.
- W2024951818 hasLocation W20249518182 @default.
- W2024951818 hasOpenAccess W2024951818 @default.
- W2024951818 hasPrimaryLocation W20249518181 @default.
- W2024951818 hasRelatedWork W117041192 @default.
- W2024951818 hasRelatedWork W1974202511 @default.
- W2024951818 hasRelatedWork W2039171719 @default.
- W2024951818 hasRelatedWork W2164161798 @default.
- W2024951818 hasRelatedWork W2175733138 @default.
- W2024951818 hasRelatedWork W222762330 @default.
- W2024951818 hasRelatedWork W2362725059 @default.
- W2024951818 hasRelatedWork W2415374653 @default.
- W2024951818 hasRelatedWork W2470664477 @default.
- W2024951818 hasRelatedWork W4380291222 @default.
- W2024951818 hasVolume "21" @default.
- W2024951818 isParatext "false" @default.
- W2024951818 isRetracted "false" @default.
- W2024951818 magId "2024951818" @default.
- W2024951818 workType "article" @default.