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- W2025764006 abstract "Glycolipid reactive natural killer T cells with an invariant TCR α-chain (iNKT cells) are a conserved population of T lymphocytes with a distinct anatomical distribution and functional properties. The differentiation pathway of iNKT cells branches off from mainstream thymocyte differentiation at the double positive stage, and recent work has revealed how signaling events early in the iNKT cell pathway imprint a memory-like behavior on these cells. Additionally, unique molecular interactions governing iNKT cell development and tissue distribution have been uncovered recently, building up our knowledge of the complex network of interactions that form this population. Novel autologous antigens for these cells have been identified, although it has not yet been resolved if there is single endogenous antigen responsible for both positive selection and/or peripheral activation." @default.
- W2025764006 created "2016-06-24" @default.
- W2025764006 creator A5016974992 @default.
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- W2025764006 date "2012-04-01" @default.
- W2025764006 modified "2023-10-02" @default.
- W2025764006 title "Making memory at birth: understanding the differentiation of natural killer T cells" @default.
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- W2025764006 doi "https://doi.org/10.1016/j.coi.2012.01.012" @default.
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