Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026011189> ?p ?o ?g. }
- W2026011189 endingPage "346" @default.
- W2026011189 startingPage "329" @default.
- W2026011189 abstract "Specific sequences (cis-acting elements) in the 3'-untranslated region (UTR) of RNA, together with stabilizing and destabilizing proteins (trans-acting factors), determine the mRNA stability, and consequently, the level of expression of several proteins. Such interactions were discovered initially for short-lived mRNAs encoding cytokines and early genes like c-jun and c-myc. However, they may also determine the fate of more stable mRNAs in a tissue and disease-dependent manner. The interactions between the cis-acting elements and the trans-acting factors may also be modulated by Ca(2+) either directly or via a control of the phosphorylation status of the trans-acting factors. We focus initially on the basic concepts in mRNA stability with the trans-acting factors AUF1 (destabilizing) and HuR (stabilizing). Sarco/endoplasmic reticulum Ca(2+) pumps, SERCA2a (cardiac and slow twitch muscles) and SERCA2b (most cells including smooth muscle cells), are pivotal in Ca(2+) mobilization during signal transduction. SERCA2a and SERCA2b proteins are encoded by relatively stable mRNAs that contain cis-acting stability determinants in their 3'-regions. We present several pathways where 3'-UTR mediated mRNA decay is key to Ca(2+) signalling: SERCA2a and beta-adrenergic receptors in heart failure, renin-angiotensin system, and parathyroid hormones. Other examples discussed include cytokines vascular endothelial growth factor, endothelin and endothelial nitric oxide synthase. Roles of Ca(2+) and Ca(2+)-binding proteins in mRNA stability are also discussed. We anticipate that these novel modes of control of protein expression will form an emerging area of research that may explore the central role of Ca(2+) in cell function during development and in disease." @default.
- W2026011189 created "2016-06-24" @default.
- W2026011189 creator A5011078652 @default.
- W2026011189 creator A5024818901 @default.
- W2026011189 creator A5054470848 @default.
- W2026011189 date "2006-10-01" @default.
- W2026011189 modified "2023-10-14" @default.
- W2026011189 title "Control of protein expression through mRNA stability in calcium signalling" @default.
- W2026011189 cites W101870996 @default.
- W2026011189 cites W147388322 @default.
- W2026011189 cites W1520989958 @default.
- W2026011189 cites W1529739927 @default.
- W2026011189 cites W1530646247 @default.
- W2026011189 cites W1569188313 @default.
- W2026011189 cites W1601279860 @default.
- W2026011189 cites W1635673699 @default.
- W2026011189 cites W1768251043 @default.
- W2026011189 cites W1783695128 @default.
- W2026011189 cites W1838293083 @default.
- W2026011189 cites W1886375502 @default.
- W2026011189 cites W1922993929 @default.
- W2026011189 cites W1963550266 @default.
- W2026011189 cites W1964616354 @default.
- W2026011189 cites W1965557392 @default.
- W2026011189 cites W1966551688 @default.
- W2026011189 cites W1968329373 @default.
- W2026011189 cites W1971860517 @default.
- W2026011189 cites W1972387093 @default.
- W2026011189 cites W1972584548 @default.
- W2026011189 cites W1973851418 @default.
- W2026011189 cites W1975130391 @default.
- W2026011189 cites W1977504093 @default.
- W2026011189 cites W1977505422 @default.
- W2026011189 cites W1977629626 @default.
- W2026011189 cites W1978501832 @default.
- W2026011189 cites W1978958505 @default.
- W2026011189 cites W1983060008 @default.
- W2026011189 cites W1985330772 @default.
- W2026011189 cites W1991405833 @default.
- W2026011189 cites W1994359940 @default.
- W2026011189 cites W1997660678 @default.
- W2026011189 cites W1999225704 @default.
- W2026011189 cites W2000786270 @default.
- W2026011189 cites W2001973462 @default.
- W2026011189 cites W2002282713 @default.
- W2026011189 cites W2003287029 @default.
- W2026011189 cites W2003334953 @default.
- W2026011189 cites W2004402054 @default.
- W2026011189 cites W2004958230 @default.
- W2026011189 cites W2006145911 @default.
- W2026011189 cites W2006547663 @default.
- W2026011189 cites W2007019068 @default.
- W2026011189 cites W2008564265 @default.
- W2026011189 cites W2008837951 @default.
- W2026011189 cites W2009441758 @default.
- W2026011189 cites W2010464551 @default.
- W2026011189 cites W2011570064 @default.
- W2026011189 cites W2013855617 @default.
- W2026011189 cites W2017253464 @default.
- W2026011189 cites W2019563964 @default.
- W2026011189 cites W2021017943 @default.
- W2026011189 cites W2025728827 @default.
- W2026011189 cites W2025817543 @default.
- W2026011189 cites W2026789634 @default.
- W2026011189 cites W2028662837 @default.
- W2026011189 cites W2030027182 @default.
- W2026011189 cites W2031807488 @default.
- W2026011189 cites W2034911857 @default.
- W2026011189 cites W2035591978 @default.
- W2026011189 cites W2036142296 @default.
- W2026011189 cites W2037079787 @default.
- W2026011189 cites W2039298735 @default.
- W2026011189 cites W2041378565 @default.
- W2026011189 cites W2042625909 @default.
- W2026011189 cites W2043185568 @default.
- W2026011189 cites W2043382556 @default.
- W2026011189 cites W2044429312 @default.
- W2026011189 cites W2047624342 @default.
- W2026011189 cites W2048028254 @default.
- W2026011189 cites W2050324319 @default.
- W2026011189 cites W2050976323 @default.
- W2026011189 cites W2052969704 @default.
- W2026011189 cites W2054580373 @default.
- W2026011189 cites W2054791134 @default.
- W2026011189 cites W2055217761 @default.
- W2026011189 cites W2055930249 @default.
- W2026011189 cites W2059212276 @default.
- W2026011189 cites W2060189686 @default.
- W2026011189 cites W2061223956 @default.
- W2026011189 cites W2061741303 @default.
- W2026011189 cites W2062593746 @default.
- W2026011189 cites W2071182758 @default.
- W2026011189 cites W2071477828 @default.
- W2026011189 cites W2071976338 @default.
- W2026011189 cites W2073421203 @default.
- W2026011189 cites W2073489209 @default.
- W2026011189 cites W2073834597 @default.
- W2026011189 cites W2074008437 @default.