FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027889716> ?p ?o ?g. }

• W2027889716 endingPage "7188" @default.
• W2027889716 startingPage "7180" @default.
• W2027889716 abstract "Custom-synthesized variants of the commercial Capto S resin were used to examine the effects of resin charge density and dextran content on protein adsorption and intraparticle uptake. For the small protein lysozyme, resin charge density had the greatest effect on equilibrium capacity, consistent with calculations suggesting that lysozyme capacity should be limited by the available charge on the resin. Isocratic retention data and confocal microscopy imaging for this protein revealed a consistent ordering of the resins linking stronger protein–resin interactions with higher static capacities but slower intraparticle uptake rates over the range of properties studied. For the larger protein lactoferrin, it was found that increasing dextran content led to increased protein exclusion from the dextran layer, but that increasing resin charge density helped overcome the exclusion, presumably due to the increased electrostatic attraction between the resin and protein. Collectively examining the lysozyme and lactoferrin data along with information from previous studies suggests that a trade-off in maximizing dynamic capacities should exist between static capacities that increase to a finite extent with increased resin charge density and uptake rates that decrease with increased charge density. Column breakthrough data for lysozyme and lactoferrin appear to support the hypothesis, though it appears that whether a resin charge density is low or high must be considered in relation to the protein charge density. Using these trends, this work could be useful in guiding resin selection or design." @default.
• W2027889716 created "2016-06-24" @default.
• W2027889716 creator A5088129278 @default.
• W2027889716 creator A5089483150 @default.
• W2027889716 date "2011-10-01" @default.
• W2027889716 modified "2023-09-23" @default.
• W2027889716 title "Protein adsorption and transport in dextran-modified ion-exchange media. III. Effects of resin charge density and dextran content on adsorption and intraparticle uptake" @default.
• W2027889716 cites W1090352659 @default.
• W2027889716 cites W1480579302 @default.
• W2027889716 cites W156107866 @default.
• W2027889716 cites W176413411 @default.
• W2027889716 cites W1964772561 @default.
• W2027889716 cites W1974421840 @default.
• W2027889716 cites W1977937489 @default.
• W2027889716 cites W1986586941 @default.
• W2027889716 cites W1993855113 @default.
• W2027889716 cites W1995915515 @default.
• W2027889716 cites W1997796797 @default.
• W2027889716 cites W1999560718 @default.
• W2027889716 cites W2001150482 @default.
• W2027889716 cites W2001287415 @default.
• W2027889716 cites W2002308830 @default.
• W2027889716 cites W2005346312 @default.
• W2027889716 cites W2012204145 @default.
• W2027889716 cites W2037204182 @default.
• W2027889716 cites W2055577146 @default.
• W2027889716 cites W2057027424 @default.
• W2027889716 cites W2063498940 @default.
• W2027889716 cites W2065206000 @default.
• W2027889716 cites W2066800013 @default.
• W2027889716 cites W2068536431 @default.
• W2027889716 cites W2069056824 @default.
• W2027889716 cites W2077092510 @default.
• W2027889716 cites W2087316284 @default.
• W2027889716 cites W2129164090 @default.
• W2027889716 cites W2146904072 @default.
• W2027889716 cites W2149363321 @default.
• W2027889716 cites W2169698033 @default.
• W2027889716 cites W4236169000 @default.
• W2027889716 cites W4238191261 @default.
• W2027889716 doi "https://doi.org/10.1016/j.chroma.2011.08.039" @default.
• W2027889716 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3600650" @default.
• W2027889716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21890143" @default.
• W2027889716 hasPublicationYear "2011" @default.
• W2027889716 type Work @default.
• W2027889716 sameAs 2027889716 @default.
• W2027889716 citedByCount "51" @default.
• W2027889716 countsByYear W20278897162012 @default.
• W2027889716 countsByYear W20278897162013 @default.
• W2027889716 countsByYear W20278897162014 @default.
• W2027889716 countsByYear W20278897162015 @default.
• W2027889716 countsByYear W20278897162016 @default.
• W2027889716 countsByYear W20278897162017 @default.
• W2027889716 countsByYear W20278897162018 @default.
• W2027889716 countsByYear W20278897162019 @default.
• W2027889716 countsByYear W20278897162020 @default.
• W2027889716 countsByYear W20278897162021 @default.
• W2027889716 countsByYear W20278897162022 @default.
• W2027889716 crossrefType "journal-article" @default.
• W2027889716 hasAuthorship W2027889716A5088129278 @default.
• W2027889716 hasAuthorship W2027889716A5089483150 @default.
• W2027889716 hasBestOaLocation W20278897162 @default.
• W2027889716 hasConcept C113196181 @default.
• W2027889716 hasConcept C121332964 @default.
• W2027889716 hasConcept C127413603 @default.
• W2027889716 hasConcept C150394285 @default.
• W2027889716 hasConcept C150708132 @default.
• W2027889716 hasConcept C178790620 @default.
• W2027889716 hasConcept C185592680 @default.
• W2027889716 hasConcept C2776966407 @default.
• W2027889716 hasConcept C2777339698 @default.
• W2027889716 hasConcept C2779170986 @default.
• W2027889716 hasConcept C42360764 @default.
• W2027889716 hasConcept C43617362 @default.
• W2027889716 hasConcept C55493867 @default.
• W2027889716 hasConcept C62520636 @default.
• W2027889716 hasConcept C73523448 @default.
• W2027889716 hasConcept C88001094 @default.
• W2027889716 hasConceptScore W2027889716C113196181 @default.
• W2027889716 hasConceptScore W2027889716C121332964 @default.
• W2027889716 hasConceptScore W2027889716C127413603 @default.
• W2027889716 hasConceptScore W2027889716C150394285 @default.
• W2027889716 hasConceptScore W2027889716C150708132 @default.
• W2027889716 hasConceptScore W2027889716C178790620 @default.
• W2027889716 hasConceptScore W2027889716C185592680 @default.
• W2027889716 hasConceptScore W2027889716C2776966407 @default.
• W2027889716 hasConceptScore W2027889716C2777339698 @default.
• W2027889716 hasConceptScore W2027889716C2779170986 @default.
• W2027889716 hasConceptScore W2027889716C42360764 @default.
• W2027889716 hasConceptScore W2027889716C43617362 @default.
• W2027889716 hasConceptScore W2027889716C55493867 @default.
• W2027889716 hasConceptScore W2027889716C62520636 @default.
• W2027889716 hasConceptScore W2027889716C73523448 @default.
• W2027889716 hasConceptScore W2027889716C88001094 @default.
• W2027889716 hasIssue "40" @default.
• W2027889716 hasLocation W20278897161 @default.
• W2027889716 hasLocation W20278897162 @default.
• W2027889716 hasLocation W20278897163 @default.

• next