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- W2029211047 endingPage "496" @default.
- W2029211047 startingPage "485" @default.
- W2029211047 abstract "Oligonucleotides containing 5-aza-7-deaza-2′-deoxyguanosine (1) were synthesized. Solid-phase synthesis was performed with the phosphonate 15 or the phosphoramidite 5. The amino-unprotected phosphonate 4 was also employed. Hybridization studies of oligonucleotides containing 1 resulted in new base pairs leading to duplexes with parallel (ps) or antiparallel (aps) chain orientation. Among those with parallel chains a stable “purine-purine” base pair was observed between 5-aza-7-deazaguanine and guanine or 7-deazaguanine. Antiparallel stranded duplexes are formed when 5-aza-7-deazaguanine pairs with cytosine. This base pair has only two hydrogen bonds under neutral conditions but is stabilized by a third one in acidic medium. A new base pair is also detected between the base of 1 and isoguanine (neutral medium)." @default.
- W2029211047 created "2016-06-24" @default.
- W2029211047 creator A5042636589 @default.
- W2029211047 creator A5060869360 @default.
- W2029211047 date "1999-02-01" @default.
- W2029211047 modified "2023-09-27" @default.
- W2029211047 title "5-Aza-7-deaza-2′-deoxyguanosine: Oligonucleotide Duplexes with Novel Base Pairs, Parallel Chain Orientation and Protonation Sites in the Core of a Double Helix" @default.
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- W2029211047 doi "https://doi.org/10.1002/(sici)1099-0690(199902)1999:2<485::aid-ejoc485>3.0.co;2-j" @default.
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