FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029910957> ?p ?o ?g. }

• W2029910957 endingPage "234" @default.
• W2029910957 startingPage "224" @default.
• W2029910957 abstract "A cell-intrinsic timer helps control when rodent oligodendrocyte precursor cells (OPCs) exit the cell cycle and terminally differentiate when cultured in platelet-derived growth factor (PDGF) and thyroid hormone (TH). There is evidence that the cyclin-dependent kinase inhibitor (CKI) p27/Kip1 (p27) is a component of this TH-regulated timer, as it increases as OPCs proliferate and is required for the timer to operate accurately. Here, we provide evidence that another CKI, p18/INK (p18), may also be a component of the timer: it increases as OPCs proliferate, and its overexpression in OPCs accelerates the timer, causing the cells to differentiate prematurely. We also show that the overexpression of p27 accelerates the timer and that the increases in both p27 and p18 that occur in proliferating OPCs are controlled posttranscriptionally. By contrast, we show that the overexpression of either p18 or p27 in OPCs proliferating in PDGF and the absence of TH greatly slows the cell cycle but fails to accelerate the spontaneous differentiation that normally occurs independently of TH." @default.
• W2029910957 created "2016-06-24" @default.
• W2029910957 creator A5000497808 @default.
• W2029910957 creator A5017938528 @default.
• W2029910957 creator A5050053589 @default.
• W2029910957 creator A5081263370 @default.
• W2029910957 date "2002-05-01" @default.
• W2029910957 modified "2023-09-23" @default.
• W2029910957 title "Posttranscriptional Regulation of p18 and p27 Cdk Inhibitor Proteins and the Timing of Oligodendrocyte Differentiation" @default.
• W2029910957 cites W1579227381 @default.
• W2029910957 cites W1900556344 @default.
• W2029910957 cites W1931479270 @default.
• W2029910957 cites W1963550744 @default.
• W2029910957 cites W1972524334 @default.
• W2029910957 cites W1974967725 @default.
• W2029910957 cites W1975324295 @default.
• W2029910957 cites W1976933447 @default.
• W2029910957 cites W1977994351 @default.
• W2029910957 cites W1980123375 @default.
• W2029910957 cites W1982845671 @default.
• W2029910957 cites W1986380537 @default.
• W2029910957 cites W1987885030 @default.
• W2029910957 cites W1991832674 @default.
• W2029910957 cites W1992245559 @default.
• W2029910957 cites W1995954654 @default.
• W2029910957 cites W1998225973 @default.
• W2029910957 cites W2000434788 @default.
• W2029910957 cites W2006659499 @default.
• W2029910957 cites W2007434276 @default.
• W2029910957 cites W2011557383 @default.
• W2029910957 cites W2033699178 @default.
• W2029910957 cites W2035143691 @default.
• W2029910957 cites W2038846947 @default.
• W2029910957 cites W2048070937 @default.
• W2029910957 cites W2050601632 @default.
• W2029910957 cites W2052935035 @default.
• W2029910957 cites W2059829192 @default.
• W2029910957 cites W2060525739 @default.
• W2029910957 cites W206238033 @default.
• W2029910957 cites W2062522473 @default.
• W2029910957 cites W2067809410 @default.
• W2029910957 cites W2069180111 @default.
• W2029910957 cites W2071250969 @default.
• W2029910957 cites W2074558188 @default.
• W2029910957 cites W2078705996 @default.
• W2029910957 cites W2081560586 @default.
• W2029910957 cites W2081870563 @default.
• W2029910957 cites W2083140708 @default.
• W2029910957 cites W2083561654 @default.
• W2029910957 cites W2085087860 @default.
• W2029910957 cites W2094859123 @default.
• W2029910957 cites W2104978120 @default.
• W2029910957 cites W2116711648 @default.
• W2029910957 cites W2121619780 @default.
• W2029910957 cites W2121802410 @default.
• W2029910957 cites W2143551857 @default.
• W2029910957 cites W2146029846 @default.
• W2029910957 cites W2146636701 @default.
• W2029910957 cites W2152534875 @default.
• W2029910957 cites W2157562526 @default.
• W2029910957 cites W2159425270 @default.
• W2029910957 cites W2221064544 @default.
• W2029910957 cites W2297276306 @default.
• W2029910957 cites W2405351417 @default.
• W2029910957 doi "https://doi.org/10.1006/dbio.2002.0626" @default.
• W2029910957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11969268" @default.
• W2029910957 hasPublicationYear "2002" @default.
• W2029910957 type Work @default.
• W2029910957 sameAs 2029910957 @default.
• W2029910957 citedByCount "64" @default.
• W2029910957 countsByYear W20299109572012 @default.
• W2029910957 countsByYear W20299109572013 @default.
• W2029910957 countsByYear W20299109572014 @default.
• W2029910957 countsByYear W20299109572015 @default.
• W2029910957 countsByYear W20299109572018 @default.
• W2029910957 countsByYear W20299109572019 @default.
• W2029910957 countsByYear W20299109572020 @default.
• W2029910957 countsByYear W20299109572021 @default.
• W2029910957 crossrefType "journal-article" @default.
• W2029910957 hasAuthorship W2029910957A5000497808 @default.
• W2029910957 hasAuthorship W2029910957A5017938528 @default.
• W2029910957 hasAuthorship W2029910957A5050053589 @default.
• W2029910957 hasAuthorship W2029910957A5081263370 @default.
• W2029910957 hasBestOaLocation W20299109571 @default.
• W2029910957 hasConcept C124320809 @default.
• W2029910957 hasConcept C1491633281 @default.
• W2029910957 hasConcept C173018170 @default.
• W2029910957 hasConcept C2776633867 @default.
• W2029910957 hasConcept C2778298596 @default.
• W2029910957 hasConcept C29537977 @default.
• W2029910957 hasConcept C41008148 @default.
• W2029910957 hasConcept C54355233 @default.
• W2029910957 hasConcept C86803240 @default.
• W2029910957 hasConcept C9390403 @default.
• W2029910957 hasConcept C95444343 @default.
• W2029910957 hasConceptScore W2029910957C124320809 @default.
• W2029910957 hasConceptScore W2029910957C1491633281 @default.
• W2029910957 hasConceptScore W2029910957C173018170 @default.

• next