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• W2030465199 abstract "The discovery of secondary metabolites produced by microorganisms (e.g., penicillin in 1928) and the beginning of their industrial application (1940) opened new doors to what has been the main medication source for the treatment of infectious diseases and tumors. In fact, approximately 80 years after the discovery of the first antibiotic compound, and despite all of the warnings about the failure of the goose that laid the golden egg, the potential of this wealth is still inexorable: simply adjust the focus from micro to nano, that means changing the look from microorganisms to nanograms of DNA. Then, the search for new drugs, driven by genetic engineering combined with metagenomic strategies, shows us a way to bypass the barriers imposed by methodologies limited to isolation and culturing. However, we are far from solving the problem of supplying new molecules that are effective against the plasticity of multi- or pan-drug-resistant pathogens. Although the first advances in genetic engineering date back to 1990, there is still a lack of high-throughput methods to speed up the screening of new genes and design new molecules by recombination of pathways. In addition, it is necessary an increase in the variety of heterologous hosts and improvements throughout the full drug discovery pipeline. Among numerous studies focused on this subject, those on polyketide antibiotics stand out for the large technical-scientific efforts that established novel solutions for the transfer/engineering of major metabolic pathways using transposons and other episomes, overcoming one of the main methodological constraints for the heterologous expression of major pathways. In silico prediction analysis of three-dimensional enzymatic structures and advances in sequencing technologies have expanded access to the metabolic potential of microorganisms." @default.
• W2030465199 created "2016-06-24" @default.
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• W2030465199 date "2013-12-01" @default.
• W2030465199 modified "2023-10-15" @default.
• W2030465199 title "Biotechnology of polyketides: new breath of life for the novel antibiotic genetic pathways discovery through metagenomics" @default.
• W2030465199 cites W1584830902 @default.
• W2030465199 cites W1967709900 @default.
• W2030465199 cites W1968418450 @default.
• W2030465199 cites W1977065668 @default.
• W2030465199 cites W1978480905 @default.
• W2030465199 cites W1982026828 @default.
• W2030465199 cites W1982784580 @default.
• W2030465199 cites W1986672838 @default.
• W2030465199 cites W1990404647 @default.
• W2030465199 cites W1993631806 @default.
• W2030465199 cites W2000176823 @default.
• W2030465199 cites W2004272533 @default.
• W2030465199 cites W2011749900 @default.
• W2030465199 cites W2012960603 @default.
• W2030465199 cites W2013030981 @default.
• W2030465199 cites W2017271290 @default.
• W2030465199 cites W2018742405 @default.
• W2030465199 cites W2025733284 @default.
• W2030465199 cites W2026974870 @default.
• W2030465199 cites W2031189156 @default.
• W2030465199 cites W2035378670 @default.
• W2030465199 cites W2037653168 @default.
• W2030465199 cites W2037988297 @default.
• W2030465199 cites W2040985535 @default.
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• W2030465199 cites W2072499238 @default.
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• W2030465199 cites W2092643722 @default.
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• W2030465199 cites W2132377217 @default.
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• W2030465199 cites W2171112999 @default.
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• W2030465199 doi "https://doi.org/10.1590/s1517-83822013000400002" @default.
• W2030465199 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3958165" @default.
• W2030465199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24688489" @default.
• W2030465199 hasPublicationYear "2013" @default.
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