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• W2031777569 abstract "Since its discovery in the early 1980s, transforming growth factor-beta (TGF-beta) has emerged as a family of growth factors involved in essential physiological processes, including embryonic development, differentiation, tissue repair and cell growth control. Knockout experiments for the three mammalian isoforms of TGF-betas in mice have demonstrated their importance in regulating inflammation and tissue repair. Also, TGF-beta has been implicated in the pathogenesis of human diseases, including tissue fibrosis and carcinogenesis where, in the latter case, it may exert both tumor suppressor and pro-oncogenic activities depending on the stage of the tumor. Cellular signaling by TGF-beta family members is initiated by the assembly of specific cell surface serine/threonine kinase type receptors that activate transcription factors of the Smad family." @default.
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• W2031777569 date "2004-07-01" @default.
• W2031777569 modified "2023-10-01" @default.
• W2031777569 title "Mammalian transforming growth factor-βs: Smad signaling and physio-pathological roles" @default.
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• W2031777569 doi "https://doi.org/10.1016/s1357-2725(03)00255-3" @default.
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