Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034839958> ?p ?o ?g. }
- W2034839958 endingPage "4055" @default.
- W2034839958 startingPage "4055" @default.
- W2034839958 abstract "Chronic hepatitis due to any cause leads to cirrhosis and end-stage liver disease. A growing body of literature has also shown that fatty liver due to overweight or obesity is a leading cause of cirrhosis. Due to the obesity epidemic, fatty liver is now a significant problem in clinical practice. Steatosis has an impact on the acceleration of liver damage in patients with chronic hepatitis due to other causes. An association between hepatitis C virus (HCV) infection, steatosis and the onset of insulin resistance has been reported. Insulin resistance is one of the leading factors for severe fibrosis in chronic HCV infections. Moreover, hyperinsulinemia has a deleterious effect on the management of chronic HCV. Response to therapy is increased by decreasing insulin resistance by weight loss or the use of thiazolidenediones or metformin. The underlying mechanisms of this complex interaction are not fully understood. A direct cytopathic effect of HCV has been suggested. The genomic structure of HCV (suggesting that some viral sequences are involved in the intracellular accumulation of triglycerides), lipid metabolism, the molecular links between the HCV core protein and lipid droplets (the core protein of HCV and its transcriptional regulatory function which induce a triglyceride accumulation in hepatocytes) and increased neolipogenesis and inhibited fatty acid degradation in mitochondria have been investigated." @default.
- W2034839958 created "2016-06-24" @default.
- W2034839958 creator A5007546876 @default.
- W2034839958 date "2011-01-01" @default.
- W2034839958 modified "2023-10-17" @default.
- W2034839958 title "Pathophysiology of insulin resistance and steatosis in patients with chronic viral hepatitis" @default.
- W2034839958 cites W1494780959 @default.
- W2034839958 cites W1534360145 @default.
- W2034839958 cites W1550916568 @default.
- W2034839958 cites W1902364422 @default.
- W2034839958 cites W1963739832 @default.
- W2034839958 cites W1965094711 @default.
- W2034839958 cites W1972088904 @default.
- W2034839958 cites W1975004114 @default.
- W2034839958 cites W1975299036 @default.
- W2034839958 cites W1978734768 @default.
- W2034839958 cites W1980672646 @default.
- W2034839958 cites W1988208946 @default.
- W2034839958 cites W1990170350 @default.
- W2034839958 cites W1998002161 @default.
- W2034839958 cites W1998009398 @default.
- W2034839958 cites W1998217764 @default.
- W2034839958 cites W2002880176 @default.
- W2034839958 cites W2003950656 @default.
- W2034839958 cites W2004866068 @default.
- W2034839958 cites W2007266674 @default.
- W2034839958 cites W2008869160 @default.
- W2034839958 cites W2009023378 @default.
- W2034839958 cites W2010139125 @default.
- W2034839958 cites W2011067202 @default.
- W2034839958 cites W2015933505 @default.
- W2034839958 cites W2017010150 @default.
- W2034839958 cites W2022763702 @default.
- W2034839958 cites W2023046253 @default.
- W2034839958 cites W2037251110 @default.
- W2034839958 cites W2038018821 @default.
- W2034839958 cites W2042144976 @default.
- W2034839958 cites W2042621509 @default.
- W2034839958 cites W2042733341 @default.
- W2034839958 cites W2050720508 @default.
- W2034839958 cites W2050941179 @default.
- W2034839958 cites W2051117650 @default.
- W2034839958 cites W2051984446 @default.
- W2034839958 cites W2053162344 @default.
- W2034839958 cites W2056333393 @default.
- W2034839958 cites W2064119981 @default.
- W2034839958 cites W2067096633 @default.
- W2034839958 cites W2067854613 @default.
- W2034839958 cites W2067902277 @default.
- W2034839958 cites W2069711307 @default.
- W2034839958 cites W2075983080 @default.
- W2034839958 cites W2077071754 @default.
- W2034839958 cites W2077260367 @default.
- W2034839958 cites W2082842671 @default.
- W2034839958 cites W2085779076 @default.
- W2034839958 cites W2087066452 @default.
- W2034839958 cites W2092422666 @default.
- W2034839958 cites W2095205890 @default.
- W2034839958 cites W209639396 @default.
- W2034839958 cites W2098831105 @default.
- W2034839958 cites W2108685753 @default.
- W2034839958 cites W2123511080 @default.
- W2034839958 cites W2124146523 @default.
- W2034839958 cites W2126317966 @default.
- W2034839958 cites W2127375111 @default.
- W2034839958 cites W2146544786 @default.
- W2034839958 cites W2148824946 @default.
- W2034839958 cites W2158974927 @default.
- W2034839958 cites W2159080529 @default.
- W2034839958 cites W2160555596 @default.
- W2034839958 cites W2335226188 @default.
- W2034839958 cites W2964947239 @default.
- W2034839958 cites W56957918 @default.
- W2034839958 doi "https://doi.org/10.3748/wjg.v17.i36.4055" @default.
- W2034839958 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3203355" @default.
- W2034839958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22039318" @default.
- W2034839958 hasPublicationYear "2011" @default.
- W2034839958 type Work @default.
- W2034839958 sameAs 2034839958 @default.
- W2034839958 citedByCount "30" @default.
- W2034839958 countsByYear W20348399582012 @default.
- W2034839958 countsByYear W20348399582013 @default.
- W2034839958 countsByYear W20348399582014 @default.
- W2034839958 countsByYear W20348399582015 @default.
- W2034839958 countsByYear W20348399582016 @default.
- W2034839958 countsByYear W20348399582017 @default.
- W2034839958 countsByYear W20348399582018 @default.
- W2034839958 countsByYear W20348399582019 @default.
- W2034839958 countsByYear W20348399582020 @default.
- W2034839958 countsByYear W20348399582021 @default.
- W2034839958 countsByYear W20348399582022 @default.
- W2034839958 countsByYear W20348399582023 @default.
- W2034839958 crossrefType "journal-article" @default.
- W2034839958 hasAuthorship W2034839958A5007546876 @default.
- W2034839958 hasBestOaLocation W20348399581 @default.
- W2034839958 hasConcept C126322002 @default.
- W2034839958 hasConcept C134018914 @default.
- W2034839958 hasConcept C203014093 @default.