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- W2034963222 endingPage "11015" @default.
- W2034963222 startingPage "11011" @default.
- W2034963222 abstract "The random addition of N nucleotides by terminal deoxynucleotidyltransferase (TdT) is an important component of the diversity of T-cell receptor genes. We have investigated the expression of TdT during thymocyte differentiation and thymus ontogeny. TdT gene transcripts are confined to immature thymocytes of the cortex, being down-regulated concomitantly with recombination-activating gene transcripts after positive selection of mature medullary T cells. According to in situ hybridization, TdT RNA is absent from the neonatal thymus, but it appears 3 to 5 days after birth, just before the appearance of significant N-region diversity in T-cell receptor junctional sequences but clearly after the thymus attains competence at clonal deletion." @default.
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- W2034963222 date "1992-11-15" @default.
- W2034963222 modified "2023-10-06" @default.
- W2034963222 title "Regulation of N-region diversity in antigen receptors through thymocyte differentiation and thymus ontogeny." @default.
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- W2034963222 doi "https://doi.org/10.1073/pnas.89.22.11011" @default.
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