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• W2036833887 abstract "• We present an account of how disease-specific animal models are established. • We take as example transgenic mice models for Alzheimer’s disease. • A three-fold validation process is introduced. • This process is oriented towards clinical relevance and scientific practices. • The incompleteness of models can be described in terms of multi-level abstraction. Animal models have received particular attention as key examples of material models. In this paper, we argue that the specificities of establishing animal models—acknowledging their status as living beings and as epistemological tools—necessitate a more complex account of animal models as materialised models. This becomes particularly evident in animal-based models of diseases that only occur in humans: in these cases, the representational relation between animal model and human patient needs to be generated and validated. The first part of this paper presents an account of how disease-specific animal models are established by drawing on the example of transgenic mice models for Alzheimer’s disease. We will introduce an account of validation that involves a three-fold process including (1) from human being to experimental organism; (2) from experimental organism to animal model; and (3) from animal model to human patient. This process draws upon clinical relevance as much as scientific practices and results in disease-specific, yet incomplete, animal models. The second part of this paper argues that the incompleteness of models can be described in terms of multi-level abstractions. We qualify this notion by pointing to different experimental techniques and targets of modelling, which give rise to a plurality of models for a specific disease." @default.
• W2036833887 created "2016-06-24" @default.
• W2036833887 creator A5033199188 @default.
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• W2036833887 date "2013-09-01" @default.
• W2036833887 modified "2023-09-26" @default.
• W2036833887 title "Mutant mice: Experimental organisms as materialised models in biomedicine" @default.
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• W2036833887 doi "https://doi.org/10.1016/j.shpsc.2013.03.001" @default.
• W2036833887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23545252" @default.
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