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• W2037297760 abstract "An easy, analytically sound fluoroenzymatic assay for angiotensin converting enzyme (ACE) inhibitors is described. Drug samples and standards are extracted with methanol and evaporated to dryness. Drug residues are then incubated with the substrate N-benzyloxycarbonyl-phenyllanyl-l-histidyl-leucine and human plasma ACE at 37 degrees C, pH 7.65, for 1 h. Fluorescence of the o-phthaldialdehyde derivatized product is measured at wavelengths of 365 nm (excitation) and 490 nm (emission). A computer program converts fluorescence to percent of ACE activity inhibited and correlates this percent inhibition with drug concentration. The ester prodrug enalapril (MK-421) was measurable at levels of a 1 ng ml(-1) in serum after base hydrolysis to enalaprilat. Lowest reliable detection limits for enalaprilat (MK-422) and lisinopril (MK-521) in serum were 0.7 ng ml(-1). This method is easily adapted to most other ACE inhibitors, is well suited to automation and avoids the use of radioactivity." @default.
• W2037297760 created "2016-06-24" @default.
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• W2037297760 date "1988-01-01" @default.
• W2037297760 modified "2023-09-27" @default.
• W2037297760 title "An optimized fluoroenzymatic assay for the determination of angiotensin converting enzyme inhibitors in biological fluids" @default.
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• W2037297760 doi "https://doi.org/10.1016/0731-7085(88)80050-5" @default.
• W2037297760 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16867414" @default.
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