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• W2038962693 endingPage "210" @default.
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• W2038962693 abstract "Mef2 transcription factors have been strongly linked with early heart development. D-mef2 is required for heart formation in Drosophila, but whether Mef2 is essential for vertebrate cardiomyocyte (CM) differentiation is unclear. In mice, although Mef2c is expressed in all CMs, targeted deletion of Mef2c causes lethal loss of second heart field (SHF) derivatives and failure of cardiac looping, but first heart field CMs can differentiate. Here we examine Mef2 function in early heart development in zebrafish. Two Mef2c genes exist in zebrafish, mef2ca and mef2cb. Both are expressed similarly in the bilateral heart fields but mef2cb is strongly expressed in the heart poles at the primitive heart tube stage. By using fish mutants for mef2ca and mef2cb and antisense morpholinos to knock down either or both Mef2cs, we show that Mef2ca and Mef2cb have essential but redundant roles in myocardial differentiation. Loss of both Mef2ca and Mef2cb function does not interfere with early cardiogenic markers such as nkx2.5, gata4 and hand2 but results in a dramatic loss of expression of sarcomeric genes and myocardial markers such as bmp4, nppa, smyd1b and late nkx2.5 mRNA. Rare residual CMs observed in mef2ca;mef2cb double mutants are ablated by a morpholino capable of knocking down other Mef2s. Mef2cb over-expression activates bmp4 within the cardiogenic region, but no ectopic CMs are formed. Surprisingly, anterior mesoderm and other tissues become skeletal muscle. Mef2ca single mutants have delayed heart development, but form an apparently normal heart. Mef2cb single mutants have a functional heart and are viable adults. Our results show that the key role of Mef2c in myocardial differentiation is conserved throughout the vertebrate heart." @default.
• W2038962693 created "2016-06-24" @default.
• W2038962693 creator A5008553714 @default.
• W2038962693 creator A5035188778 @default.
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• W2038962693 creator A5040710180 @default.
• W2038962693 creator A5078878888 @default.
• W2038962693 creator A5087073583 @default.
• W2038962693 date "2012-09-01" @default.
• W2038962693 modified "2023-10-02" @default.
• W2038962693 title "Zebrafish Mef2ca and Mef2cb are essential for both first and second heart field cardiomyocyte differentiation" @default.
• W2038962693 cites W1600642794 @default.
• W2038962693 cites W1867816903 @default.
• W2038962693 cites W1931060259 @default.
• W2038962693 cites W1965271063 @default.
• W2038962693 cites W1966563415 @default.
• W2038962693 cites W1966586235 @default.
• W2038962693 cites W1969670626 @default.
• W2038962693 cites W1971977081 @default.
• W2038962693 cites W1972638695 @default.
• W2038962693 cites W1981186391 @default.
• W2038962693 cites W1981311462 @default.
• W2038962693 cites W1989731833 @default.
• W2038962693 cites W1997803767 @default.
• W2038962693 cites W1997971733 @default.
• W2038962693 cites W2000647402 @default.
• W2038962693 cites W2002732720 @default.
• W2038962693 cites W2003369513 @default.
• W2038962693 cites W2012743859 @default.
• W2038962693 cites W2013756638 @default.
• W2038962693 cites W2013835313 @default.
• W2038962693 cites W2017517482 @default.
• W2038962693 cites W2023206260 @default.
• W2038962693 cites W2025855348 @default.
• W2038962693 cites W2026960397 @default.
• W2038962693 cites W2027153571 @default.
• W2038962693 cites W2027727178 @default.
• W2038962693 cites W2033871452 @default.
• W2038962693 cites W2034923868 @default.
• W2038962693 cites W2039124939 @default.
• W2038962693 cites W2041898322 @default.
• W2038962693 cites W2042376011 @default.
• W2038962693 cites W2047582685 @default.
• W2038962693 cites W2048861391 @default.
• W2038962693 cites W2049240721 @default.
• W2038962693 cites W2049783720 @default.
• W2038962693 cites W2051026229 @default.
• W2038962693 cites W2051258900 @default.
• W2038962693 cites W2054653907 @default.
• W2038962693 cites W2059621170 @default.
• W2038962693 cites W2066092773 @default.
• W2038962693 cites W2066122906 @default.
• W2038962693 cites W2070293940 @default.
• W2038962693 cites W2070314600 @default.
• W2038962693 cites W2073187339 @default.
• W2038962693 cites W2075401648 @default.
• W2038962693 cites W2078422108 @default.
• W2038962693 cites W2091760375 @default.
• W2038962693 cites W2093968919 @default.
• W2038962693 cites W2094651478 @default.
• W2038962693 cites W2096132763 @default.
• W2038962693 cites W2097222175 @default.
• W2038962693 cites W2097672164 @default.
• W2038962693 cites W2103724167 @default.
• W2038962693 cites W2103968215 @default.
• W2038962693 cites W2106438297 @default.
• W2038962693 cites W2106468261 @default.
• W2038962693 cites W2109418446 @default.
• W2038962693 cites W2109762243 @default.
• W2038962693 cites W2111479560 @default.
• W2038962693 cites W2112431248 @default.
• W2038962693 cites W2117147389 @default.
• W2038962693 cites W2120609231 @default.
• W2038962693 cites W2122967431 @default.
• W2038962693 cites W2125295969 @default.
• W2038962693 cites W2126137248 @default.
• W2038962693 cites W2127634027 @default.
• W2038962693 cites W2129248963 @default.
• W2038962693 cites W2134253526 @default.
• W2038962693 cites W2143149809 @default.
• W2038962693 cites W2146927398 @default.
• W2038962693 cites W2150681906 @default.
• W2038962693 cites W2153361555 @default.
• W2038962693 cites W2155651653 @default.
• W2038962693 cites W2156999640 @default.
• W2038962693 cites W2157132717 @default.
• W2038962693 cites W2158900245 @default.
• W2038962693 cites W2159270639 @default.
• W2038962693 cites W2160487610 @default.
• W2038962693 cites W2161322544 @default.
• W2038962693 cites W2161959672 @default.
• W2038962693 cites W2163698312 @default.
• W2038962693 cites W2164386538 @default.
• W2038962693 cites W2167202160 @default.
• W2038962693 cites W4242474794 @default.
• W2038962693 doi "https://doi.org/10.1016/j.ydbio.2012.06.019" @default.
• W2038962693 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3927553" @default.
• W2038962693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22750409" @default.

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