Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039771260> ?p ?o ?g. }
- W2039771260 endingPage "227" @default.
- W2039771260 startingPage "221" @default.
- W2039771260 abstract "The membrane-proximal external region (MPER) of gp41 is considered as a prime target for the induction of neutralizing antibodies, since it contains the epitopes for three broadly neutralizing antibodies (2F5, 4E10 and Z13). Here we present a novel gp41 construct (HA-gp41) comprising gp41 HR2 and MPER fused to two triple-stranded coiled-coil domains at both ends. HA-gp41 is trimeric, has a high helical content in solution and forms rod-like structures as revealed by negative staining electron microscopy. Immunization of rabbits with HA-gp41 induced antibodies directed against MPER, which failed to exert significant neutralization capacity against envelopes from primary isolates. Thus trimerisation of MPER regions does not suffice to induce a potent neutralizing antibody response specific for conserved regions within gp41." @default.
- W2039771260 created "2016-06-24" @default.
- W2039771260 creator A5004036928 @default.
- W2039771260 creator A5016163665 @default.
- W2039771260 creator A5022716555 @default.
- W2039771260 creator A5027445812 @default.
- W2039771260 creator A5044652616 @default.
- W2039771260 creator A5067385882 @default.
- W2039771260 creator A5076995891 @default.
- W2039771260 creator A5080175927 @default.
- W2039771260 creator A5082786145 @default.
- W2039771260 date "2009-08-01" @default.
- W2039771260 modified "2023-09-24" @default.
- W2039771260 title "Characterization of a trimeric MPER containing HIV-1 gp41 antigen" @default.
- W2039771260 cites W1570460604 @default.
- W2039771260 cites W1587830797 @default.
- W2039771260 cites W1635348995 @default.
- W2039771260 cites W1794879226 @default.
- W2039771260 cites W1888509701 @default.
- W2039771260 cites W1909984710 @default.
- W2039771260 cites W1966616903 @default.
- W2039771260 cites W1970409794 @default.
- W2039771260 cites W1973844352 @default.
- W2039771260 cites W1981433958 @default.
- W2039771260 cites W1989164610 @default.
- W2039771260 cites W1991093481 @default.
- W2039771260 cites W1998371035 @default.
- W2039771260 cites W1998987175 @default.
- W2039771260 cites W2004643638 @default.
- W2039771260 cites W2013399404 @default.
- W2039771260 cites W2014812897 @default.
- W2039771260 cites W2029540605 @default.
- W2039771260 cites W2031637541 @default.
- W2039771260 cites W2033645653 @default.
- W2039771260 cites W2038114373 @default.
- W2039771260 cites W2046427690 @default.
- W2039771260 cites W2047921952 @default.
- W2039771260 cites W2048719253 @default.
- W2039771260 cites W2048982317 @default.
- W2039771260 cites W2051611676 @default.
- W2039771260 cites W2053336940 @default.
- W2039771260 cites W2055834697 @default.
- W2039771260 cites W2059502096 @default.
- W2039771260 cites W2063701397 @default.
- W2039771260 cites W2067107443 @default.
- W2039771260 cites W2069141624 @default.
- W2039771260 cites W2072278974 @default.
- W2039771260 cites W2083094268 @default.
- W2039771260 cites W2083391421 @default.
- W2039771260 cites W2084310667 @default.
- W2039771260 cites W2090763940 @default.
- W2039771260 cites W2091209917 @default.
- W2039771260 cites W2095910488 @default.
- W2039771260 cites W2097594050 @default.
- W2039771260 cites W2102548388 @default.
- W2039771260 cites W2105364254 @default.
- W2039771260 cites W2106197125 @default.
- W2039771260 cites W2109673912 @default.
- W2039771260 cites W2113963476 @default.
- W2039771260 cites W2122015693 @default.
- W2039771260 cites W2123788666 @default.
- W2039771260 cites W2127072493 @default.
- W2039771260 cites W2127939214 @default.
- W2039771260 cites W2131623743 @default.
- W2039771260 cites W2132895335 @default.
- W2039771260 cites W2137939749 @default.
- W2039771260 cites W2144831378 @default.
- W2039771260 cites W2150397848 @default.
- W2039771260 cites W2151805116 @default.
- W2039771260 cites W2154012446 @default.
- W2039771260 cites W2156841733 @default.
- W2039771260 cites W2157272520 @default.
- W2039771260 cites W2158181429 @default.
- W2039771260 cites W2162546635 @default.
- W2039771260 cites W2165499430 @default.
- W2039771260 cites W2175342233 @default.
- W2039771260 cites W2177434887 @default.
- W2039771260 cites W2329251934 @default.
- W2039771260 cites W30316958 @default.
- W2039771260 cites W4241040961 @default.
- W2039771260 doi "https://doi.org/10.1016/j.virol.2009.05.015" @default.
- W2039771260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19539967" @default.
- W2039771260 hasPublicationYear "2009" @default.
- W2039771260 type Work @default.
- W2039771260 sameAs 2039771260 @default.
- W2039771260 citedByCount "32" @default.
- W2039771260 countsByYear W20397712602012 @default.
- W2039771260 countsByYear W20397712602013 @default.
- W2039771260 countsByYear W20397712602014 @default.
- W2039771260 countsByYear W20397712602015 @default.
- W2039771260 countsByYear W20397712602016 @default.
- W2039771260 countsByYear W20397712602019 @default.
- W2039771260 countsByYear W20397712602020 @default.
- W2039771260 crossrefType "journal-article" @default.
- W2039771260 hasAuthorship W2039771260A5004036928 @default.
- W2039771260 hasAuthorship W2039771260A5016163665 @default.
- W2039771260 hasAuthorship W2039771260A5022716555 @default.
- W2039771260 hasAuthorship W2039771260A5027445812 @default.