Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039846685> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2039846685 endingPage "445" @default.
- W2039846685 startingPage "435" @default.
- W2039846685 abstract "Cis-parinaric acid is fluorescent when partioned into a lipid environment and its fluorescence is destroyed upon reaction with free radicals. In our study 1-palmitoyl-2-parinoyl-phosphatidylcholine (cis-PnA) has been used to monitor the time-course of liposomal lipid peroxidation, using reverse-phase evaporation vesicles (REV) of different composition exposed to oxidative stress in various conditions. This methodology allowed us to estimate the potential damage produced by two different oxidizing systems, namely hydrogen peroxide (H2O2), a water soluble oxidant, and t-butyl hydroperoxide (t-BHP), a hydrophobic hydroperoxide. Furthermore, we evaluated the protective effects of bilayer-associated antioxidants, namely alpha-tocopherol acetate (alpha-THA), vitamin K1 and beta-carotene, as well as of two antioxidants dissolved in the aqueous bulk solution, that is, biverdin and uric acid. Under our experimental conditions, the results suggest that (i) both oxidizing compounds were able to interact with liposomal PnA leading to decay either of the excitation and of emission spectra of the probe; (ii) hydrogen peroxide seemed to be of most effective among the two stressing agents, when employed at similar concentrations; (iii) the alpha-THA appeared to be a stronger antioxidant than vitamin K1 and beta-carotene, resulting in a decrease of the liposomal membrane stress caused by those two oxidizing agents; (iv) among the water soluble antioxidant compounds, biliverdin displayed a protective effect at least 10 x higher than uric acid; (v) the overall damage, as well as the protection mechanisms, seemed to be dependent either on the lipid composition of the vesicles and on the pH of the liposomal suspension. This relatively easy experimental approach suggests the validity of the use of the bilayer associated fluorescent probe PnA in the monitoring of spontaneous and/or chemically induced liposomal lipid damage." @default.
- W2039846685 created "2016-06-24" @default.
- W2039846685 creator A5005904457 @default.
- W2039846685 creator A5013988424 @default.
- W2039846685 creator A5029199217 @default.
- W2039846685 creator A5046975305 @default.
- W2039846685 date "1996-01-01" @default.
- W2039846685 modified "2023-09-25" @default.
- W2039846685 title "Monitoring by cis-parinaric fluorescence of free radical induced lipid peroxidation in aqueous liposome suspensions" @default.
- W2039846685 cites W1879184430 @default.
- W2039846685 cites W1967257968 @default.
- W2039846685 cites W1973489372 @default.
- W2039846685 cites W1974685965 @default.
- W2039846685 cites W1978775022 @default.
- W2039846685 cites W1982553378 @default.
- W2039846685 cites W1991649520 @default.
- W2039846685 cites W1992697830 @default.
- W2039846685 cites W2003901365 @default.
- W2039846685 cites W2037467201 @default.
- W2039846685 cites W2038675827 @default.
- W2039846685 cites W2053399043 @default.
- W2039846685 cites W2058523499 @default.
- W2039846685 cites W2060081825 @default.
- W2039846685 cites W2074993698 @default.
- W2039846685 cites W2075208263 @default.
- W2039846685 cites W2092707622 @default.
- W2039846685 cites W2116628043 @default.
- W2039846685 cites W2138887253 @default.
- W2039846685 doi "https://doi.org/10.3109/02652049609026029" @default.
- W2039846685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8808780" @default.
- W2039846685 hasPublicationYear "1996" @default.
- W2039846685 type Work @default.
- W2039846685 sameAs 2039846685 @default.
- W2039846685 citedByCount "5" @default.
- W2039846685 crossrefType "journal-article" @default.
- W2039846685 hasAuthorship W2039846685A5005904457 @default.
- W2039846685 hasAuthorship W2039846685A5013988424 @default.
- W2039846685 hasAuthorship W2039846685A5029199217 @default.
- W2039846685 hasAuthorship W2039846685A5046975305 @default.
- W2039846685 hasConcept C139066938 @default.
- W2039846685 hasConcept C178790620 @default.
- W2039846685 hasConcept C184651966 @default.
- W2039846685 hasConcept C185154212 @default.
- W2039846685 hasConcept C185592680 @default.
- W2039846685 hasConcept C2776151105 @default.
- W2039846685 hasConcept C2778004101 @default.
- W2039846685 hasConcept C2780829032 @default.
- W2039846685 hasConcept C533411734 @default.
- W2039846685 hasConcept C55493867 @default.
- W2039846685 hasConcept C75473681 @default.
- W2039846685 hasConcept C77176794 @default.
- W2039846685 hasConceptScore W2039846685C139066938 @default.
- W2039846685 hasConceptScore W2039846685C178790620 @default.
- W2039846685 hasConceptScore W2039846685C184651966 @default.
- W2039846685 hasConceptScore W2039846685C185154212 @default.
- W2039846685 hasConceptScore W2039846685C185592680 @default.
- W2039846685 hasConceptScore W2039846685C2776151105 @default.
- W2039846685 hasConceptScore W2039846685C2778004101 @default.
- W2039846685 hasConceptScore W2039846685C2780829032 @default.
- W2039846685 hasConceptScore W2039846685C533411734 @default.
- W2039846685 hasConceptScore W2039846685C55493867 @default.
- W2039846685 hasConceptScore W2039846685C75473681 @default.
- W2039846685 hasConceptScore W2039846685C77176794 @default.
- W2039846685 hasIssue "4" @default.
- W2039846685 hasLocation W20398466851 @default.
- W2039846685 hasLocation W20398466852 @default.
- W2039846685 hasOpenAccess W2039846685 @default.
- W2039846685 hasPrimaryLocation W20398466851 @default.
- W2039846685 hasRelatedWork W1162079594 @default.
- W2039846685 hasRelatedWork W1470000624 @default.
- W2039846685 hasRelatedWork W1997186820 @default.
- W2039846685 hasRelatedWork W2015611030 @default.
- W2039846685 hasRelatedWork W2064319133 @default.
- W2039846685 hasRelatedWork W2355378129 @default.
- W2039846685 hasRelatedWork W2470477812 @default.
- W2039846685 hasRelatedWork W2750703310 @default.
- W2039846685 hasRelatedWork W4214942380 @default.
- W2039846685 hasRelatedWork W4229333834 @default.
- W2039846685 hasVolume "13" @default.
- W2039846685 isParatext "false" @default.
- W2039846685 isRetracted "false" @default.
- W2039846685 magId "2039846685" @default.
- W2039846685 workType "article" @default.