FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040315989> ?p ?o ?g. }

• W2040315989 endingPage "520" @default.
• W2040315989 startingPage "512" @default.
• W2040315989 abstract "Abstract. Clinical evidence points to disturbed calcium metabolism in lead (Pb) intoxication. To further clarify the mechanisms involved, serum levels of 1,25(OH)2D3, receptors for 1,25(OH)2D3 as well as size and ultrastructure of parathyroid glands were examined in Wistar Kyoto rats exposed to 1% lead (Pb) acetate in drinking water for 10 weeks (short-term study) or 0·001 – 1 % Pb acetate for 24 weeks (long-term study). After administration of Pb for 10 weeks, bone Pb was significantly increased (641±66·9 (SD) vs. 0·648±0·39 mg kg-1 ash in controls). Total serum calcium and ionized Ca2+ (1·15±0·031 vs. 1·25±0·03 mmol 1-1) were significantly decreased. Renal function (Ccr) was unchanged, but urinary cAMP excretion and circulating 1,25(OH)2D3 (177±10·9 vs. 232±18·9 pmol 1-1) were diminished. Specific binding of 1,25(OH)2D3 was increased in parathyroids (Bmax 128±4·7 vs. 108±0·6 fmol mg-1 protein) and intestinal mucosa; Bmax failed to adequately rise in response to pretreatment with 1,25(OH)2D3 (2·10 ng day-1 for 4 d) in Pb-exposed animals. Receptor characteristics (sedimentation constant, KD, DNA affinity) were unchanged. Parathyroid weight was significantly increased (178·25 vs. 96·34 μg) with no change of estimated nuclear volume, cell volume or cell ultrastructure. After 24 weeks of Pb exposure, a dose-dependent but non-linear increase of parathyroid weight was noted between 0·001% and 1% Pb in drinking fluid. The present study documents secondary hyperparathyroidism associated with, and presumably caused by, hypocalcaemia and low 1,25(OH)2D3 levels, in experimental Pb intoxication." @default.
• W2040315989 created "2016-06-24" @default.
• W2040315989 creator A5005850493 @default.
• W2040315989 creator A5019372763 @default.
• W2040315989 creator A5022731076 @default.
• W2040315989 creator A5046297316 @default.
• W2040315989 creator A5047112417 @default.
• W2040315989 creator A5087875804 @default.
• W2040315989 date "1991-10-01" @default.
• W2040315989 modified "2023-09-25" @default.
• W2040315989 title "Hyperparathyroidism and abnormal 1,25(OH)2vitamin D3metabolism in experimental lead intoxication" @default.
• W2040315989 cites W1538644438 @default.
• W2040315989 cites W1896778737 @default.
• W2040315989 cites W1964764779 @default.
• W2040315989 cites W1982557516 @default.
• W2040315989 cites W1984489053 @default.
• W2040315989 cites W1996475346 @default.
• W2040315989 cites W2010430461 @default.
• W2040315989 cites W2011921884 @default.
• W2040315989 cites W2012365339 @default.
• W2040315989 cites W2012385276 @default.
• W2040315989 cites W2018429484 @default.
• W2040315989 cites W2022290320 @default.
• W2040315989 cites W2038943153 @default.
• W2040315989 cites W2046397527 @default.
• W2040315989 cites W2048078487 @default.
• W2040315989 cites W2053372319 @default.
• W2040315989 cites W2054432696 @default.
• W2040315989 cites W2065336148 @default.
• W2040315989 cites W2068831921 @default.
• W2040315989 cites W2076655658 @default.
• W2040315989 cites W2078509120 @default.
• W2040315989 cites W2078656123 @default.
• W2040315989 cites W2090942068 @default.
• W2040315989 cites W2099137918 @default.
• W2040315989 cites W2158005891 @default.
• W2040315989 cites W2158651421 @default.
• W2040315989 cites W2169027518 @default.
• W2040315989 cites W2173187023 @default.
• W2040315989 cites W2318117556 @default.
• W2040315989 cites W2335340708 @default.
• W2040315989 cites W4230250846 @default.
• W2040315989 cites W4256730882 @default.
• W2040315989 doi "https://doi.org/10.1111/j.1365-2362.1991.tb01403.x" @default.
• W2040315989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1661238" @default.
• W2040315989 hasPublicationYear "1991" @default.
• W2040315989 type Work @default.
• W2040315989 sameAs 2040315989 @default.
• W2040315989 citedByCount "4" @default.
• W2040315989 countsByYear W20403159892019 @default.
• W2040315989 countsByYear W20403159892023 @default.
• W2040315989 crossrefType "journal-article" @default.
• W2040315989 hasAuthorship W2040315989A5005850493 @default.
• W2040315989 hasAuthorship W2040315989A5019372763 @default.
• W2040315989 hasAuthorship W2040315989A5022731076 @default.
• W2040315989 hasAuthorship W2040315989A5046297316 @default.
• W2040315989 hasAuthorship W2040315989A5047112417 @default.
• W2040315989 hasAuthorship W2040315989A5087875804 @default.
• W2040315989 hasConcept C126322002 @default.
• W2040315989 hasConcept C134018914 @default.
• W2040315989 hasConcept C170493617 @default.
• W2040315989 hasConcept C185592680 @default.
• W2040315989 hasConcept C2775945674 @default.
• W2040315989 hasConcept C2778248654 @default.
• W2040315989 hasConcept C2778838027 @default.
• W2040315989 hasConcept C2779224224 @default.
• W2040315989 hasConcept C2781208988 @default.
• W2040315989 hasConcept C29730261 @default.
• W2040315989 hasConcept C519063684 @default.
• W2040315989 hasConcept C71924100 @default.
• W2040315989 hasConcept C87975464 @default.
• W2040315989 hasConceptScore W2040315989C126322002 @default.
• W2040315989 hasConceptScore W2040315989C134018914 @default.
• W2040315989 hasConceptScore W2040315989C170493617 @default.
• W2040315989 hasConceptScore W2040315989C185592680 @default.
• W2040315989 hasConceptScore W2040315989C2775945674 @default.
• W2040315989 hasConceptScore W2040315989C2778248654 @default.
• W2040315989 hasConceptScore W2040315989C2778838027 @default.
• W2040315989 hasConceptScore W2040315989C2779224224 @default.
• W2040315989 hasConceptScore W2040315989C2781208988 @default.
• W2040315989 hasConceptScore W2040315989C29730261 @default.
• W2040315989 hasConceptScore W2040315989C519063684 @default.
• W2040315989 hasConceptScore W2040315989C71924100 @default.
• W2040315989 hasConceptScore W2040315989C87975464 @default.
• W2040315989 hasIssue "5" @default.
• W2040315989 hasLocation W20403159891 @default.
• W2040315989 hasLocation W20403159892 @default.
• W2040315989 hasOpenAccess W2040315989 @default.
• W2040315989 hasPrimaryLocation W20403159891 @default.
• W2040315989 hasRelatedWork W106823581 @default.
• W2040315989 hasRelatedWork W1916986742 @default.
• W2040315989 hasRelatedWork W1987877535 @default.
• W2040315989 hasRelatedWork W1996475346 @default.
• W2040315989 hasRelatedWork W2013378793 @default.
• W2040315989 hasRelatedWork W2040315989 @default.
• W2040315989 hasRelatedWork W2065156827 @default.
• W2040315989 hasRelatedWork W2067994365 @default.
• W2040315989 hasRelatedWork W2113790635 @default.

• next