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- W2040463804 abstract "Embryonic stem cells (ESCs) are able to self-renew and to differentiate into all somatic cell types, a property termed “pluripotency.” To maintain these remarkable properties ESCs must silence the genes responsible for differentiation, but in a manner compatible with later activation. Developmental gene silencing is dependent on the Polycomb repressor complexes (PRCs), histone modifiers whose loss in ESCs leads to differentiation. PRCrepressed genes may also be occupied by active histone modifications, and the balance of both activators and repressors was thought to provide developmental genes with the potential for subsequent activation. We previously showed that PRCrepressed genes could also be bound by RNA Polymerase II (RNAPII) and transcribed. However, the prevalence of this configuration across the ESC genome was unclear, and whether activating RNAPII and silencing PRC could bind simultaneously was not tested. This is especially pertinent considering recent discussion of the heterogeneity of ESC populations, caused by dynamic fluctuations in transcription factor levels. Furthermore, cells asynchronously cycle in culture, so a snapshot of “co-occupancy” may reflect antagonistic complexes switching on and off the chromatin at distinct time points. To elucidate the interplay between RNAPII and PRCs across the ESC genome, we generated genome-wide maps of the modifications which occur to RNAPII as it progresses through the transcription cycle. RNAPII modifications are dispensable for its enzymatic activity, per se, but play critical roles in Code breaking The RNAPII modification code in pluripotency" @default.
- W2040463804 created "2016-06-24" @default.
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- W2040463804 date "2012-04-01" @default.
- W2040463804 modified "2023-09-26" @default.
- W2040463804 title "Code breaking: The RNAPII modification code in pluripotency" @default.
- W2040463804 doi "https://doi.org/10.4161/cc.19990" @default.
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