FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042603198> ?p ?o ?g. }

• W2042603198 endingPage "273" @default.
• W2042603198 startingPage "266" @default.
• W2042603198 abstract "When compared with other U.S. populations, African Americans have excess hypertension. Genetic variants in elements of the renin-angiotensin-aldosterone system (RAAS), namely the angiotensin-converting enzyme (ACE), aldosterone synthase (CYP11B2), and angiotensin II type 1 receptor (AGTR1) genes, have been associated with risk of hypertension in some populations.We genotyped the D/I polymorphism in the ACE gene, the C(-344)T polymorphism in the CYP11B2 gene, and the C(-535)T polymorphism in the AGTR1 gene among African American and Latino members of the Multiethnic Cohort Study (MEC) to determine their association with hypertension.We observed no significant increase in the risk of hypertension for either African Americans or Latinos homozygous or heterozygous for the D allele of the ACE gene. Among African Americans we observed carriers of the (-344)T allele of CYP11B2 to be at increased risk of hypertension (versus CC genotype: TC genotype, OR = 1.66 [95% CI: 1.01-2.72]; TT genotype, OR = 1.74 [95% CI: 1.07-2.82]). There was also an increase in risk of hypertension associated with the AGTR1 T allele for African Americans (versus CC genotype: TC genotype, OR = 2.62 [95% CI: 1.46-4.72]; TT genotype, OR = 2.67 [95% CI: 1.51-4.74]). The associations observed with CYP11B2 and AGTR1 genotypes were not observed among Latinos.These data suggest that the (-535)T allele of AGTR1 and (-344)T allele of CYP11B2 may increase hypertension risk among African Americans but not among Latinos. Characterization of the linkage disequilibrium and haplotype patterns in the RAAS pathway genes will be crucial to understanding differences in hypertension susceptibility in these ethnic populations." @default.
• W2042603198 created "2016-06-24" @default.
• W2042603198 creator A5005674169 @default.
• W2042603198 creator A5063459619 @default.
• W2042603198 creator A5066527817 @default.
• W2042603198 date "2004-11-01" @default.
• W2042603198 modified "2023-10-10" @default.
• W2042603198 title "Multiple Polymorphisms in the Renin-Angiotensin-Aldosterone System (ACE, CYP11B2, AGTR1) and Their Contribution to Hypertension in African Americans and Latinos in the Multiethnic Cohort" @default.
• W2042603198 cites W1963895441 @default.
• W2042603198 cites W1966894016 @default.
• W2042603198 cites W1968912609 @default.
• W2042603198 cites W1980207137 @default.
• W2042603198 cites W1985770217 @default.
• W2042603198 cites W1988966853 @default.
• W2042603198 cites W1995608289 @default.
• W2042603198 cites W2004869835 @default.
• W2042603198 cites W2008085210 @default.
• W2042603198 cites W2012287896 @default.
• W2042603198 cites W2013709047 @default.
• W2042603198 cites W2026732703 @default.
• W2042603198 cites W2033347969 @default.
• W2042603198 cites W2047471660 @default.
• W2042603198 cites W2051618380 @default.
• W2042603198 cites W2063167493 @default.
• W2042603198 cites W2066160129 @default.
• W2042603198 cites W2070304005 @default.
• W2042603198 cites W2071961805 @default.
• W2042603198 cites W2087119797 @default.
• W2042603198 cites W2092270440 @default.
• W2042603198 cites W2095017107 @default.
• W2042603198 cites W2097532633 @default.
• W2042603198 cites W2115047102 @default.
• W2042603198 cites W2119114835 @default.
• W2042603198 cites W2119334879 @default.
• W2042603198 cites W2121991119 @default.
• W2042603198 cites W2123899458 @default.
• W2042603198 cites W2124066321 @default.
• W2042603198 cites W2134270369 @default.
• W2042603198 cites W2135207001 @default.
• W2042603198 cites W2139376627 @default.
• W2042603198 cites W2140882931 @default.
• W2042603198 cites W2145366887 @default.
• W2042603198 cites W2151458434 @default.
• W2042603198 cites W2158957320 @default.
• W2042603198 cites W2160406258 @default.
• W2042603198 cites W2161212879 @default.
• W2042603198 cites W2166501331 @default.
• W2042603198 cites W2314183680 @default.
• W2042603198 cites W2323212303 @default.
• W2042603198 cites W2341536947 @default.
• W2042603198 cites W2342115977 @default.
• W2042603198 cites W287195306 @default.
• W2042603198 doi "https://doi.org/10.1097/00000441-200411000-00006" @default.
• W2042603198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15545843" @default.
• W2042603198 hasPublicationYear "2004" @default.
• W2042603198 type Work @default.
• W2042603198 sameAs 2042603198 @default.
• W2042603198 citedByCount "43" @default.
• W2042603198 countsByYear W20426031982012 @default.
• W2042603198 countsByYear W20426031982013 @default.
• W2042603198 countsByYear W20426031982015 @default.
• W2042603198 countsByYear W20426031982016 @default.
• W2042603198 countsByYear W20426031982018 @default.
• W2042603198 countsByYear W20426031982019 @default.
• W2042603198 countsByYear W20426031982020 @default.
• W2042603198 countsByYear W20426031982021 @default.
• W2042603198 crossrefType "journal-article" @default.
• W2042603198 hasAuthorship W2042603198A5005674169 @default.
• W2042603198 hasAuthorship W2042603198A5063459619 @default.
• W2042603198 hasAuthorship W2042603198A5066527817 @default.
• W2042603198 hasConcept C104317684 @default.
• W2042603198 hasConcept C126322002 @default.
• W2042603198 hasConcept C134018914 @default.
• W2042603198 hasConcept C135763542 @default.
• W2042603198 hasConcept C180754005 @default.
• W2042603198 hasConcept C198710026 @default.
• W2042603198 hasConcept C2777097880 @default.
• W2042603198 hasConcept C2778525890 @default.
• W2042603198 hasConcept C2780249997 @default.
• W2042603198 hasConcept C2908929049 @default.
• W2042603198 hasConcept C54355233 @default.
• W2042603198 hasConcept C71924100 @default.
• W2042603198 hasConcept C72563966 @default.
• W2042603198 hasConcept C84393581 @default.
• W2042603198 hasConcept C86803240 @default.
• W2042603198 hasConceptScore W2042603198C104317684 @default.
• W2042603198 hasConceptScore W2042603198C126322002 @default.
• W2042603198 hasConceptScore W2042603198C134018914 @default.
• W2042603198 hasConceptScore W2042603198C135763542 @default.
• W2042603198 hasConceptScore W2042603198C180754005 @default.
• W2042603198 hasConceptScore W2042603198C198710026 @default.
• W2042603198 hasConceptScore W2042603198C2777097880 @default.
• W2042603198 hasConceptScore W2042603198C2778525890 @default.
• W2042603198 hasConceptScore W2042603198C2780249997 @default.
• W2042603198 hasConceptScore W2042603198C2908929049 @default.
• W2042603198 hasConceptScore W2042603198C54355233 @default.
• W2042603198 hasConceptScore W2042603198C71924100 @default.
• W2042603198 hasConceptScore W2042603198C72563966 @default.

• next