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- W2043001404 abstract "Flow cytometric DNA analysis was performed on 203 paraffinembedded archival specimens obtained from patients with surgical stage I endometrial carcinoma. Primary therapy for those patients (1979–1983) had been definitive extirpation with adjuvant therapy determined by histologic grade, histologic subtype, myometrial invasion, and peritoneal cytologic findings. Diploid DNA patterns were identified in 171 (84%) specimens and nondiploid characteristics were observed in the remaining 32 (25 DNA aneuploid, 7 DNA tetraploid). Although DNA nondiploid specimen accounted for only 16% of all stage I patients, they accounted for 50% of all relapses. Regardless of treatment or other pathologic features, progression-free 5-year Kaplan-Meier survival estimates were 92 and 63% for patients with DNA diploid and DNA nondiploid patterns, respectively (P < 0.001). Overall 5-year progression-free survival for patients with grade 1 or 2 lesions was 90%; stratification by DNA diploid and DNA nondiploid patterns revealed progression-free survivals of 94 and 64%, respectively (P < 0.001). Peritoneal cytologic study was positive in seven patients; none of the five with a DNA diploid pattern had a relapse and both with the DNA nondiploid pattern had relapses. These studies suggest that DNA ploidy status may be an objective prognostic determinant for patients with stage I endometrial carcinoma." @default.
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- W2043001404 date "1989-09-01" @default.
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- W2043001404 title "Flow cytometric DNA analysis of stage I endometrial carcinoma" @default.
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- W2043001404 doi "https://doi.org/10.1016/0090-8258(89)90165-0" @default.
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