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- W2043053060 abstract "The surface O-antigen polymers of gram-negative bacteria exhibit a modal length distribution that depends on dedicated chain length regulator periplasmic proteins (polysaccharide co-polymerases, PCPs) anchored in the inner membrane by two transmembrane helices. In an attempt to determine whether structural changes underlie the O-antigen modal length specification, we have determined the crystal structures of several closely related PCPs, namely two chimeric PCP-1 family members solved at 1.6 and 2.8 Å and a wild-type PCP-1 from Shigella flexneri solved at 2.8 Å. The chimeric proteins form circular octamers, whereas the wild-type WzzB from S. flexneri was found to be an open trimer. We also present the structure of a Wzz(FepE) mutant, which exhibits severe attenuation in its ability to produce very long O-antigen polymers. Our findings suggest that the differences in the modal length distribution depend primarily on the surface-exposed amino acids in specific regions rather than on the differences in the oligomeric state of the PCP protomers." @default.
- W2043053060 created "2016-06-24" @default.
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- W2043053060 date "2012-05-01" @default.
- W2043053060 modified "2023-10-14" @default.
- W2043053060 title "Structural Characterization of Closely Related O-antigen Lipopolysaccharide (LPS) Chain Length Regulators" @default.
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- W2043053060 doi "https://doi.org/10.1074/jbc.m112.354837" @default.
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