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• W2044386418 endingPage "e28106" @default.
• W2044386418 startingPage "e28106" @default.
• W2044386418 abstract "During development, the growth of the animal body is accompanied by a concomitant elongation of the peripheral nerves, which requires the elongation of integrated nerve fibers and the axons projecting therein. Although this process is of fundamental importance to almost all organisms of the animal kingdom, very little is known about the mechanisms regulating this process. Here, we describe the identification and characterization of novel mutant alleles of GlcAT-P, the Drosophila ortholog of the mammalian glucuronyltransferase b3gat1. GlcAT-P mutants reveal shorter larval peripheral nerves and an elongated ventral nerve cord (VNC). We show that GlcAT-P is expressed in a subset of neurons in the central brain hemispheres, in some motoneurons of the ventral nerve cord as well as in central and peripheral nerve glia. We demonstrate that in GlcAT-P mutants the VNC is under tension of shorter peripheral nerves suggesting that the VNC elongates as a consequence of tension imparted by retarded peripheral nerve growth during larval development. We also provide evidence that for growth of peripheral nerve fibers GlcAT-P is critically required in hemocytes; however, glial cells are also important in this process. The glial specific repo gene acts as a modifier of GlcAT-P and loss or reduction of repo function in a GlcAT-P mutant background enhances VNC elongation. We propose a model in which hemocytes are required for aspects of glial cell biology which in turn affects the elongation of peripheral nerves during larval development. Our data also identifies GlcAT-P as a first candidate gene involved in growth of integrated peripheral nerves and therefore establishes Drosophila as an amenable in-vivo model system to study this process at the cellular and molecular level in more detail." @default.
• W2044386418 created "2016-06-24" @default.
• W2044386418 creator A5022105218 @default.
• W2044386418 creator A5059758147 @default.
• W2044386418 creator A5063176412 @default.
• W2044386418 date "2011-11-23" @default.
• W2044386418 modified "2023-09-25" @default.
• W2044386418 title "The Glucuronyltransferase GlcAT-P Is Required for Stretch Growth of Peripheral Nerves in Drosophila" @default.
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• W2044386418 doi "https://doi.org/10.1371/journal.pone.0028106" @default.
• W2044386418 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3223219" @default.
• W2044386418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22132223" @default.
• W2044386418 hasPublicationYear "2011" @default.
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