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- W2045387175 abstract "Objectives: Depolarizing (hyperkalemic) solutions are widely used to preserve organs for transplantation and for cardiac operations. We previously observed that exposure to hyperkalemia reduced endothelium-dependent, noncyclooxygenase- and non–nitric oxide–mediated relaxation. This study was designed to examine the mechanism of this effect with regard to K channels and the associated membrane potential changes. Methods: Porcine coronary artery rings were studied in organ chambers. After incubation of the tissue with 20 or 50 mmol/L doses of potassium for 1 hour, the endothelium-derived hyperpolarizing factor–mediated relaxation in the artery and the membrane hyperpolarization in a single coronary smooth muscle cell were studied. Results: The endothelium-derived hyperpolarizing factor–mediated relaxation induced by substance P, which could be significantly inhibited by the Ca2+-activated K channel blocker tetraethylammonium but only to a lesser extent by the adenosine triphosphate–sensitive K channel blocker glibenclamide, was significantly reduced. Substance P–induced hyperpolarization of the membrane potential was also significantly reduced by the hyperkalemic incubation with a significantly elevated resting membrane potential. Conclusions: Depolarizing arrest reduces endothelium-derived hyperpolarizing factor–mediated membrane hyperpolarization and relaxation by affecting mainly the Ca2+-activated K channels and by depolarizing the membrane for a prolonged period. We suggest that this is one of the mechanisms for coronary dysfunction after exposure to depolarizing (hyperkalemic) cardioplegic and organ-preservation solutions and that, therefore, “perfect” protection of the heart or other organs should restore the endothelium-derived hyperpolarizing factor–related endothelial function. (J Thorac Cardiovasc Surg 1997;113:932-41)" @default.
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- W2045387175 date "1997-05-01" @default.
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- W2045387175 title "Depolarizing cardiac arrest and endothelium-derived hyperpolarizing factor–mediated hyperpolarization and relaxation in coronary arteries: The effect and mechanism" @default.
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- W2045387175 doi "https://doi.org/10.1016/s0022-5223(97)70267-8" @default.
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