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• W2045586150 endingPage "463" @default.
• W2045586150 startingPage "457" @default.
• W2045586150 abstract "In the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, the initiation of DNA replication is controlled at a point called START. At this point, the cellular environment is assessed; only if conditions are appropriate do cells traverse START, thus becoming committed to initiate DNA replication and complete the remainder of the cell cycle. The cdc2+/CDC28+ gene, encoding the protein kinase p34, is a key element in this complex control. The identification of structural and functional homologues of p34 suggests that it has a role in the control of DNA replication in all eukaryotes. The WHI1+, CLN1+ and CLN2+ gene products, identified in S. cerevisiae, are positive regulators that function at START and may interact with p34. Determining how passing the START control point leads to the initiation of DNA replication is a major outstanding challenge in cell cycle studies." @default.
• W2045586150 created "2016-06-24" @default.
• W2045586150 creator A5000148033 @default.
• W2045586150 creator A5019124036 @default.
• W2045586150 date "1990-10-01" @default.
• W2045586150 modified "2023-09-26" @default.
• W2045586150 title "Yeast as a model system for understanding the control of DNA replication in eukaryotes" @default.
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• W2045586150 doi "https://doi.org/10.1002/bies.950121002" @default.
• W2045586150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2082935" @default.
• W2045586150 hasPublicationYear "1990" @default.
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