Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046103854> ?p ?o ?g. }
- W2046103854 endingPage "337" @default.
- W2046103854 startingPage "331" @default.
- W2046103854 abstract "Organophosphate (OP) compounds as anticholinesterase agents may secondarily act on diverse serine hydrolase targets, revealing unfavorable physiological effects including male reproductive toxicity. The present investigation proposes that fenitrothion (FNT, a major OP compound) acts on the endocannabinoid signaling system in male reproductive organs, thereby leading to spermatotoxicity (sperm deformity, underdevelopment, and reduced motility) in rats. FNT oxon (bioactive metabolite of FNT) preferentially inhibited the fatty acid amide hydrolase (FAAH), an endocannabinoid anandamide (AEA) hydrolase, in the rat cellular membrane preparation from the testis in vitro. Subsequently, male Wistar rats were treated orally with 5 or 10mg/kg FNT for 9 weeks and the subchronic exposure unambiguously deteriorated sperm motility and morphology. The activity-based protein profiling analysis with a phosphonofluoridate fluorescent probe revealed that FAAH was selectively inhibited among the FNT-treated cellular membrane proteome in testis. Intriguingly, testicular AEA (endogenous substrate of FAAH) levels were elevated along with the FAAH inhibition caused by the subchronic exposure. More importantly, linear regression analyses for the FNT-elicited spermatotoxicity reveal a good correlation between the testicular FAAH activity and morphological indices or sperm motility. Accordingly, the present study proposes that the FNT-elicited spermatotoxicity appears to be related to inhibition of FAAH leading to overstimulation of the endocannabinoid signaling system, which plays crucial roles in spermatogenesis and sperm motility acquirement." @default.
- W2046103854 created "2016-06-24" @default.
- W2046103854 creator A5008702973 @default.
- W2046103854 creator A5011137466 @default.
- W2046103854 creator A5017198249 @default.
- W2046103854 creator A5019798541 @default.
- W2046103854 creator A5046454314 @default.
- W2046103854 creator A5057783383 @default.
- W2046103854 creator A5067037595 @default.
- W2046103854 creator A5068670495 @default.
- W2046103854 creator A5076994948 @default.
- W2046103854 creator A5081691633 @default.
- W2046103854 date "2014-09-01" @default.
- W2046103854 modified "2023-09-27" @default.
- W2046103854 title "Fenitrothion action at the endocannabinoid system leading to spermatotoxicity in Wistar rats" @default.
- W2046103854 cites W1508578930 @default.
- W2046103854 cites W1701529362 @default.
- W2046103854 cites W1975419826 @default.
- W2046103854 cites W1976344821 @default.
- W2046103854 cites W1979938143 @default.
- W2046103854 cites W1991866072 @default.
- W2046103854 cites W1996111288 @default.
- W2046103854 cites W1997055530 @default.
- W2046103854 cites W1999536031 @default.
- W2046103854 cites W1999769731 @default.
- W2046103854 cites W2007930970 @default.
- W2046103854 cites W2010955280 @default.
- W2046103854 cites W2019387110 @default.
- W2046103854 cites W2020768534 @default.
- W2046103854 cites W2031212289 @default.
- W2046103854 cites W2043967497 @default.
- W2046103854 cites W2046537958 @default.
- W2046103854 cites W2048768773 @default.
- W2046103854 cites W2051331667 @default.
- W2046103854 cites W2055333968 @default.
- W2046103854 cites W2061804225 @default.
- W2046103854 cites W2063762175 @default.
- W2046103854 cites W2066307290 @default.
- W2046103854 cites W2078038493 @default.
- W2046103854 cites W2081242345 @default.
- W2046103854 cites W2087250130 @default.
- W2046103854 cites W2092032044 @default.
- W2046103854 cites W2097913296 @default.
- W2046103854 cites W2099134637 @default.
- W2046103854 cites W2101792150 @default.
- W2046103854 cites W2102260997 @default.
- W2046103854 cites W2108474339 @default.
- W2046103854 cites W2145890655 @default.
- W2046103854 cites W2149102265 @default.
- W2046103854 cites W2155196648 @default.
- W2046103854 cites W2163971257 @default.
- W2046103854 cites W2171335364 @default.
- W2046103854 cites W2172249841 @default.
- W2046103854 doi "https://doi.org/10.1016/j.taap.2014.06.023" @default.
- W2046103854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24998969" @default.
- W2046103854 hasPublicationYear "2014" @default.
- W2046103854 type Work @default.
- W2046103854 sameAs 2046103854 @default.
- W2046103854 citedByCount "13" @default.
- W2046103854 countsByYear W20461038542015 @default.
- W2046103854 countsByYear W20461038542016 @default.
- W2046103854 countsByYear W20461038542017 @default.
- W2046103854 countsByYear W20461038542018 @default.
- W2046103854 countsByYear W20461038542019 @default.
- W2046103854 countsByYear W20461038542020 @default.
- W2046103854 countsByYear W20461038542021 @default.
- W2046103854 countsByYear W20461038542023 @default.
- W2046103854 crossrefType "journal-article" @default.
- W2046103854 hasAuthorship W2046103854A5008702973 @default.
- W2046103854 hasAuthorship W2046103854A5011137466 @default.
- W2046103854 hasAuthorship W2046103854A5017198249 @default.
- W2046103854 hasAuthorship W2046103854A5019798541 @default.
- W2046103854 hasAuthorship W2046103854A5046454314 @default.
- W2046103854 hasAuthorship W2046103854A5057783383 @default.
- W2046103854 hasAuthorship W2046103854A5067037595 @default.
- W2046103854 hasAuthorship W2046103854A5068670495 @default.
- W2046103854 hasAuthorship W2046103854A5076994948 @default.
- W2046103854 hasAuthorship W2046103854A5081691633 @default.
- W2046103854 hasConcept C126322002 @default.
- W2046103854 hasConcept C134018914 @default.
- W2046103854 hasConcept C148001335 @default.
- W2046103854 hasConcept C161176658 @default.
- W2046103854 hasConcept C170493617 @default.
- W2046103854 hasConcept C181199279 @default.
- W2046103854 hasConcept C185592680 @default.
- W2046103854 hasConcept C2776414213 @default.
- W2046103854 hasConcept C2776588719 @default.
- W2046103854 hasConcept C2777632594 @default.
- W2046103854 hasConcept C2778938600 @default.
- W2046103854 hasConcept C2779783865 @default.
- W2046103854 hasConcept C2780900081 @default.
- W2046103854 hasConcept C2781087480 @default.
- W2046103854 hasConcept C2781144285 @default.
- W2046103854 hasConcept C46721173 @default.
- W2046103854 hasConcept C55493867 @default.
- W2046103854 hasConcept C58207958 @default.
- W2046103854 hasConcept C59822182 @default.
- W2046103854 hasConcept C6557445 @default.