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• W2046263826 endingPage "1671" @default.
• W2046263826 startingPage "1662" @default.
• W2046263826 abstract "ABSTRACT At the midblastula transition, the Xenopus laevis embryonic cell cycle is remodeled from rapid alternations between S and M phases to become the complex adult cell cycle. Cell cycle remodeling occurs after zygotic transcription initiates and is accompanied by terminal downregulation of maternal cyclins A1 and B2. We report here that the disappearance of both cyclin A1 and B2 proteins is preceded by the rapid deadenylation of their mRNAs. A specific mechanism triggers this deadenylation. This mechanism depends upon discrete regions of the 3′ untranslated regions and requires zygotic transcription. Together, these results strongly suggest that zygote-dependent deadenylation of cyclin A1 and cyclin B2 mRNAs is responsible for the downregulation of these proteins. These studies also raise the possibility that zygotic control of maternal cyclins plays a role in establishing the adult cell cycle." @default.
• W2046263826 created "2016-06-24" @default.
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• W2046263826 date "2001-03-01" @default.
• W2046263826 modified "2023-10-12" @default.
• W2046263826 title "Zygotic Regulation of Maternal Cyclin A1 and B2 mRNAs" @default.
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• W2046263826 doi "https://doi.org/10.1128/mcb.21.5.1662-1671.2001" @default.
• W2046263826 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/86712" @default.
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