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- W2046509049 abstract "In this study, we newly synthesized caged compounds of L-leucyl-L-leucine methyl ester and examined their photochemical and immunological properties. From the viewpoints of solubility in phosphate-buffered saline containing 1% dimethyl sulfoxide as well as photoreactivity, we chose two caged compounds, 1 and 2, for study. Upon irradiation, L-leucyl-L-leucine methyl ester with a trans-o-hydroxycinnamoyl group (1) releases L-leucyl-L-leucine methyl ester quite slowly, whereas L-leucyl-L-leucine methyl ester with an o-nitrobenzyl group (2) releases L-leucyl-L-leucine methyl ester quickly. Both irradiated compounds induced apoptosis of U937 cells, as evidenced by a decrease in cell size, although 1 itself caused necrosis (cell swelling) of these cells." @default.
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- W2046509049 date "1995-08-01" @default.
- W2046509049 modified "2023-10-14" @default.
- W2046509049 title "Synthesis of Caged Compounds of L-Leucyl-L-Leucine Methyl Ester, an Apoptosis Inducer, and Their Cytotoxic Activity" @default.
- W2046509049 doi "https://doi.org/10.1006/bbrc.1995.2181" @default.
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