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• W2047820059 abstract "Abstract Objectives/Hypothesis Cisplatin ototoxicity is a major dose‐limiting factor in the treatment of several neoplasms. Vitamin E, a slow‐acting free radical scavenger, has been shown to ameliorate nephrotoxicity and endothelial cell damage in animals receiving cisplatin. The purpose of the study was to determine the effectiveness of vitamin E as an otoprotectant. Study Design Prospective, randomized controlled trial in the rat model. Methods Wistar rats (weight, 261–386 g) were sedated using 172.4 mg/kg intramuscular ketamine and 3.4 mg/kg xylazine. Baseline auditory brainstem response (ABR) testing was performed in response to clicks and 8‐, 16‐, and 32‐kHz tone bursts. After auditory thresholds were determined, the animals received intraperitoneal drug administration according to one of three group classifications. Group 1 received 4 g/kg vitamin E followed after 30 minutes by 16 mg/kg cisplatin. Group 2 received 6 mL/kg soybean oil followed after 30 minutes by cisplatin. Group 3 received soybean oil followed after 30 minutes by 16 mL/kg saline. After 3 days' follow‐up, ABR testing was performed and threshold changes were recorded. Cochleae were removed and processed for scanning electron microscopy after follow‐up auditory testing was carried out. Results Group 2 animals showed marked hearing loss with average threshold shifts of 28.75 ± 2.3 dB for clicks, 30.0 ± 1.9 dB at 8 kHz, 21.25 ± 4.0 dB at 16 kHz, and 45.0 ± 4.2 dB at 32 kHz. No significant loss was observed in group 3 with shifts of 2 ± 1.3 dB, 3 ± 3.0 dB, −2.2 ± 3.1 dB, and −1.1 ± 4.0 dB for clicks and tone bursts at 8, 16, and 32 kHz, respectively. Significant protection was seen in group 1 animals compared with group 2 animals. In the former group, threshold shifts of 12.5 ± 3.1 dB for clicks, 7.5 ± 2.5 dB at 8 kHz, 5.0 ± 3.3 dB at 16 kHz, and 24.4 ± 5.6 dB at 32 kHz were observed. These findings were supported by the scanning electron microscope observations that severe outer hair cell destruction occurred in group 2 rats, whereas outer hair cells were preserved to a much greater extent in the cochleae of rats in group 1 that were pretreated with vitamin E. Conclusion Vitamin E appears to have a protective effect against cisplatin ototoxicity." @default.
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• W2047820059 date "2004-03-01" @default.
• W2047820059 modified "2023-10-10" @default.
• W2047820059 title "Vitamin E Reduces Cisplatin Ototoxicity" @default.
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• W2047820059 doi "https://doi.org/10.1097/00005537-200403000-00028" @default.
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