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• W2048157860 abstract "Malathion, a commonly used insecticide, is reported to be genotoxic in various test systems both in vivo and in vitro. However, no report on its genotoxic activity in avian test system could be found. In the present study, the genotoxic potential of technical grade malathion was investigated in chick in vivo. Malathion (2.5, 5, 10 mg/kg) induced significant dose-dependent increase in the frequency of micronuclei (MN) in the bone marrow cells following i.p. as well as p.o. routes of exposure. A significant decrease in mitotic index (MI) was observed for the highest dose (10 mg/kg) tested. In the peripheral blood cells, significant increase in the frequency of MN could be observed for the higher doses (5, 10 mg/kg) tested. Our results indicate that technical grade malathion may be considered as a mutagenic compound in chicks and is cytotoxic at higher doses." @default.
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• W2048157860 date "2002-01-01" @default.
• W2048157860 modified "2023-10-14" @default.
• W2048157860 title "Genotoxic Effects of Malathion in Chick in Vivo Micronucleus Assay." @default.
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• W2048157860 doi "https://doi.org/10.1508/cytologia.67.53" @default.
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