Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053526872> ?p ?o ?g. }
- W2053526872 endingPage "S37" @default.
- W2053526872 startingPage "S20" @default.
- W2053526872 abstract "New advancements have emerged in the field of hepatocellular carcinoma (HCC) in recent years. There has been a switch in the type of presentation of HCC in developed countries, with a clear increase of tumors <2 cm in diameter as a result of the wide implementation of surveillance programs. Non-invasive radiological techniques have been developed and validated for the diagnosis of small and tiny HCCs. Simultaneously, diagnostic criteria based on molecular profiling of early tumors have been proposed. The current clinical classification of HCC divides patients into 5 stages with a specific treatment-oriented schedule. There is no established molecular classification of HCC, although preliminary proposals have already been published. Advancements in the treatment arena have come from well designed trials. Radiofrequency ablation is currently consolidated as providing better local control of the disease compared with percutaneous ethanol injection. New devices are available to improve the anti-tumoral efficacy of conventional chemoembolization. Sorafenib, a multikinase inhibitor, has shown survival benefits in patients at advanced stages of the disease. This advancement represents a breakthrough in the management of this complex disease, and proves that molecular targeted therapies can be effective in this otherwise chemo-resistant tumor. Consequently, sorafenib will become the standard of care in advanced cases, and the control arm for future trials. Now, the research effort faces other areas of unmet need, such as the adjuvant setting of resection/local ablation and combination therapies." @default.
- W2053526872 created "2016-06-24" @default.
- W2053526872 creator A5052975894 @default.
- W2053526872 creator A5080019152 @default.
- W2053526872 date "2008-01-01" @default.
- W2053526872 modified "2023-10-04" @default.
- W2053526872 title "Novel advancements in the management of hepatocellular carcinoma in 2008" @default.
- W2053526872 cites W175518023 @default.
- W2053526872 cites W1860868308 @default.
- W2053526872 cites W1963919405 @default.
- W2053526872 cites W1964042756 @default.
- W2053526872 cites W1966116691 @default.
- W2053526872 cites W1966636348 @default.
- W2053526872 cites W1969489445 @default.
- W2053526872 cites W1969886925 @default.
- W2053526872 cites W1971663334 @default.
- W2053526872 cites W1974507188 @default.
- W2053526872 cites W1974744928 @default.
- W2053526872 cites W1975154077 @default.
- W2053526872 cites W1976304781 @default.
- W2053526872 cites W1985897897 @default.
- W2053526872 cites W1985922618 @default.
- W2053526872 cites W1987689694 @default.
- W2053526872 cites W1989603707 @default.
- W2053526872 cites W1990073288 @default.
- W2053526872 cites W1990199684 @default.
- W2053526872 cites W1992131464 @default.
- W2053526872 cites W1993128964 @default.
- W2053526872 cites W1996523527 @default.
- W2053526872 cites W1998495520 @default.
- W2053526872 cites W1999948868 @default.
- W2053526872 cites W2000249913 @default.
- W2053526872 cites W2000681830 @default.
- W2053526872 cites W2003984225 @default.
- W2053526872 cites W2007601283 @default.
- W2053526872 cites W2007787939 @default.
- W2053526872 cites W2011043511 @default.
- W2053526872 cites W2015755710 @default.
- W2053526872 cites W2017987948 @default.
- W2053526872 cites W2020215421 @default.
- W2053526872 cites W2020830322 @default.
- W2053526872 cites W2021299297 @default.
- W2053526872 cites W2023815439 @default.
- W2053526872 cites W2025016366 @default.
- W2053526872 cites W2025890159 @default.
- W2053526872 cites W2027025001 @default.
- W2053526872 cites W2029945171 @default.
- W2053526872 cites W2030726979 @default.
- W2053526872 cites W2031007088 @default.
- W2053526872 cites W2033802014 @default.
- W2053526872 cites W2034039470 @default.
- W2053526872 cites W2037245133 @default.
- W2053526872 cites W2039394834 @default.
- W2053526872 cites W2045775115 @default.
- W2053526872 cites W2049608574 @default.
- W2053526872 cites W2052552898 @default.
- W2053526872 cites W2059079639 @default.
- W2053526872 cites W2059207532 @default.
- W2053526872 cites W2059485540 @default.
- W2053526872 cites W2060050131 @default.
- W2053526872 cites W2061345986 @default.
- W2053526872 cites W2062790352 @default.
- W2053526872 cites W2063741110 @default.
- W2053526872 cites W2065589690 @default.
- W2053526872 cites W2067691895 @default.
- W2053526872 cites W2071586107 @default.
- W2053526872 cites W2072554662 @default.
- W2053526872 cites W2073195217 @default.
- W2053526872 cites W2080321731 @default.
- W2053526872 cites W2081176013 @default.
- W2053526872 cites W2083674344 @default.
- W2053526872 cites W2085048557 @default.
- W2053526872 cites W2088629624 @default.
- W2053526872 cites W2090293099 @default.
- W2053526872 cites W2096376421 @default.
- W2053526872 cites W2099657378 @default.
- W2053526872 cites W2099789788 @default.
- W2053526872 cites W2101031676 @default.
- W2053526872 cites W2105027040 @default.
- W2053526872 cites W2106285087 @default.
- W2053526872 cites W2106307128 @default.
- W2053526872 cites W2111077571 @default.
- W2053526872 cites W2115001053 @default.
- W2053526872 cites W2115497785 @default.
- W2053526872 cites W2120059488 @default.
- W2053526872 cites W2120875761 @default.
- W2053526872 cites W2124471593 @default.
- W2053526872 cites W2125763116 @default.
- W2053526872 cites W2126214330 @default.
- W2053526872 cites W2130325374 @default.
- W2053526872 cites W2130830460 @default.
- W2053526872 cites W2130978854 @default.
- W2053526872 cites W2131212067 @default.
- W2053526872 cites W2131357269 @default.
- W2053526872 cites W2132395321 @default.
- W2053526872 cites W2133348533 @default.
- W2053526872 cites W2138059780 @default.
- W2053526872 cites W2139297732 @default.