Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053535211> ?p ?o ?g. }
- W2053535211 endingPage "4763" @default.
- W2053535211 startingPage "4758" @default.
- W2053535211 abstract "Steroid receptors bind as dimers to a degenerate set of response elements containing inverted repeats of a hexameric half-site separated by 3 bp of spacer (IR3). Naturally occurring selective androgen response elements have recently been identified that resemble direct repeats of the hexameric half-site (ADR3). The 3D crystal structure of the androgen receptor (AR) DNA-binding domain bound to a selective ADR3 reveals an unexpected head-to-head arrangement of the two protomers rather than the expected head-to-tail arrangement seen in nuclear receptors bound to response elements of similar geometry. Compared with the glucocorticoid receptor, the DNA-binding domain dimer interface of the AR has additional interactions that stabilize the AR dimer and increase the affinity for nonconsensus response elements. This increased interfacial stability compared with the other steroid receptors may account for the selective binding of AR to ADR3 response elements." @default.
- W2053535211 created "2016-06-24" @default.
- W2053535211 creator A5025708679 @default.
- W2053535211 creator A5033781254 @default.
- W2053535211 creator A5037496059 @default.
- W2053535211 creator A5037570217 @default.
- W2053535211 creator A5090338913 @default.
- W2053535211 date "2004-03-22" @default.
- W2053535211 modified "2023-10-01" @default.
- W2053535211 title "Structural basis of androgen receptor binding to selective androgen response elements" @default.
- W2053535211 cites W1539796472 @default.
- W2053535211 cites W1607714362 @default.
- W2053535211 cites W1766657157 @default.
- W2053535211 cites W1965277349 @default.
- W2053535211 cites W1970409287 @default.
- W2053535211 cites W1976983409 @default.
- W2053535211 cites W1980409632 @default.
- W2053535211 cites W1985247182 @default.
- W2053535211 cites W1985865142 @default.
- W2053535211 cites W1987183940 @default.
- W2053535211 cites W1993635973 @default.
- W2053535211 cites W1995017064 @default.
- W2053535211 cites W2003651427 @default.
- W2053535211 cites W2005385197 @default.
- W2053535211 cites W2012698052 @default.
- W2053535211 cites W2012879549 @default.
- W2053535211 cites W2013083986 @default.
- W2053535211 cites W2017223203 @default.
- W2053535211 cites W2019671667 @default.
- W2053535211 cites W2020952430 @default.
- W2053535211 cites W2026324836 @default.
- W2053535211 cites W2032129833 @default.
- W2053535211 cites W2033965812 @default.
- W2053535211 cites W2041512194 @default.
- W2053535211 cites W2041781038 @default.
- W2053535211 cites W2044203168 @default.
- W2053535211 cites W2047505345 @default.
- W2053535211 cites W2050509563 @default.
- W2053535211 cites W2057611301 @default.
- W2053535211 cites W2059415631 @default.
- W2053535211 cites W2063835289 @default.
- W2053535211 cites W2065209749 @default.
- W2053535211 cites W2073786155 @default.
- W2053535211 cites W2077854579 @default.
- W2053535211 cites W2079577861 @default.
- W2053535211 cites W2079706694 @default.
- W2053535211 cites W2087659682 @default.
- W2053535211 cites W2116750520 @default.
- W2053535211 cites W2130463690 @default.
- W2053535211 cites W2132185105 @default.
- W2053535211 cites W2139494246 @default.
- W2053535211 cites W2140506590 @default.
- W2053535211 cites W2149026172 @default.
- W2053535211 cites W2172256092 @default.
- W2053535211 cites W2292736786 @default.
- W2053535211 cites W2730913318 @default.
- W2053535211 cites W4246400933 @default.
- W2053535211 doi "https://doi.org/10.1073/pnas.0401123101" @default.
- W2053535211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/387321" @default.
- W2053535211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15037741" @default.
- W2053535211 hasPublicationYear "2004" @default.
- W2053535211 type Work @default.
- W2053535211 sameAs 2053535211 @default.
- W2053535211 citedByCount "339" @default.
- W2053535211 countsByYear W20535352112012 @default.
- W2053535211 countsByYear W20535352112013 @default.
- W2053535211 countsByYear W20535352112014 @default.
- W2053535211 countsByYear W20535352112015 @default.
- W2053535211 countsByYear W20535352112016 @default.
- W2053535211 countsByYear W20535352112017 @default.
- W2053535211 countsByYear W20535352112018 @default.
- W2053535211 countsByYear W20535352112019 @default.
- W2053535211 countsByYear W20535352112020 @default.
- W2053535211 countsByYear W20535352112021 @default.
- W2053535211 countsByYear W20535352112022 @default.
- W2053535211 countsByYear W20535352112023 @default.
- W2053535211 crossrefType "journal-article" @default.
- W2053535211 hasAuthorship W2053535211A5025708679 @default.
- W2053535211 hasAuthorship W2053535211A5033781254 @default.
- W2053535211 hasAuthorship W2053535211A5037496059 @default.
- W2053535211 hasAuthorship W2053535211A5037570217 @default.
- W2053535211 hasAuthorship W2053535211A5090338913 @default.
- W2053535211 hasBestOaLocation W20535352112 @default.
- W2053535211 hasConcept C104317684 @default.
- W2053535211 hasConcept C107824862 @default.
- W2053535211 hasConcept C121608353 @default.
- W2053535211 hasConcept C12554922 @default.
- W2053535211 hasConcept C170493617 @default.
- W2053535211 hasConcept C178790620 @default.
- W2053535211 hasConcept C185592680 @default.
- W2053535211 hasConcept C2777911890 @default.
- W2053535211 hasConcept C2779546866 @default.
- W2053535211 hasConcept C2780192828 @default.
- W2053535211 hasConcept C2780902042 @default.
- W2053535211 hasConcept C33987129 @default.
- W2053535211 hasConcept C51445715 @default.
- W2053535211 hasConcept C530470458 @default.
- W2053535211 hasConcept C54355233 @default.