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- W2053681811 abstract "During late postnatal development, mice with the autosomal recessive wobbler mutation (wr/wr) develop motoneuron degeneration associated with astrogliosis in the spinal cord. In vitro, primary wobbler astrocytes are also affected, exhibiting abnormal cell–cell contacts. To characterize further the wobbler disease, we investigated the in vitro effects of wobbler astrocytes on primary neuronal cultures from the spinal cords of 15-day-old wild-type mouse and rat embryos. Cocultures with the wobbler astrocytes, or direct addition of wobbler astrocyte-conditioned medium, led to a decrease in neuron number in primary mixed neuronal cultures, containing motoneurons and interneuron-like cells. In contrast, wobbler astrocyte-conditioned medium enhanced survival of highly purified motoneurons. These in vitro results suggest the possibility that wobbler astrocytes act not on motoneurons directly but, rather, through other spinal neurons to induce motoneuron degeneration in the wobbler disease. J. Neurosci. Res. 59:100–106, 2000 © 2000 Wiley-Liss, Inc." @default.
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- W2053681811 date "2000-01-01" @default.
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- W2053681811 title "Influence of factors secreted byWobbler astrocytes on neuronal and motoneuronal survival" @default.
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- W2053681811 doi "https://doi.org/10.1002/(sici)1097-4547(20000101)59:1<100::aid-jnr12>3.0.co;2-5" @default.
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