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- W2056397792 abstract "Background Brain noradrenaline is involved in footshock stress-induced reinstatement of drug seeking in a rat relapse model. We studied whether yohimbine, an α-2 adrenoceptor antagonist that increases noradrenaline release and induces anxiety-like responses in human and nonhuman subjects, would reinstate methamphetamine seeking in rats. Methods In experiment 1, the effect of yohimbine (1.25–2.5 mg/kg) on reinstatement was compared with that of intermittent footshock (5 min; .2–.6 mA) in rats that were trained to lever press for intravenous methamphetamine (9–11 days) and subsequently underwent 7 days of extinction training. In experiment 2, the effect of yohimbine on reinstatement of drug seeking was determined during early (1 day) and late (21 or 51 days) withdrawal periods. On the test days, rats were first given 3-hour extinction sessions and were then tested for reinstatement induced by yohimbine. Results In experiment 1, both yohimbine and footshock stress reinstated methamphetamine seeking after extinction. In experiment 2, extinction responding was higher after 21 or 51 withdrawal days than after 1 withdrawal day. In contrast, no significant time-dependent changes in yohimbine-induced reinstatement were observed. Conclusions Results indicate that yohimbine is a potent stimulus for reinstatement of methamphetamine seeking in a rat relapse model." @default.
- W2056397792 created "2016-06-24" @default.
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- W2056397792 date "2004-06-01" @default.
- W2056397792 modified "2023-10-01" @default.
- W2056397792 title "The anxiogenic drug yohimbine reinstates methamphetamine seeking in a rat model of drug relapse" @default.
- W2056397792 cites W1574751342 @default.
- W2056397792 cites W1671645500 @default.
- W2056397792 cites W1754082247 @default.
- W2056397792 cites W1920823193 @default.
- W2056397792 cites W1964528322 @default.
- W2056397792 cites W1968721836 @default.
- W2056397792 cites W1974215173 @default.
- W2056397792 cites W1977709009 @default.
- W2056397792 cites W1977756547 @default.
- W2056397792 cites W1980225069 @default.
- W2056397792 cites W1981112641 @default.
- W2056397792 cites W1982935931 @default.
- W2056397792 cites W1983960474 @default.
- W2056397792 cites W1984346427 @default.
- W2056397792 cites W1985525186 @default.
- W2056397792 cites W1986498233 @default.
- W2056397792 cites W1992295593 @default.
- W2056397792 cites W1995208764 @default.
- W2056397792 cites W1999113647 @default.
- W2056397792 cites W2007501509 @default.
- W2056397792 cites W2012580675 @default.
- W2056397792 cites W2020598149 @default.
- W2056397792 cites W2022391976 @default.
- W2056397792 cites W2023397088 @default.
- W2056397792 cites W2023564789 @default.
- W2056397792 cites W2027434266 @default.
- W2056397792 cites W2028219379 @default.
- W2056397792 cites W2028360502 @default.
- W2056397792 cites W2030310872 @default.
- W2056397792 cites W2033579793 @default.
- W2056397792 cites W2033584583 @default.
- W2056397792 cites W2035266273 @default.
- W2056397792 cites W2040903782 @default.
- W2056397792 cites W2041421210 @default.
- W2056397792 cites W2044823814 @default.
- W2056397792 cites W2049950135 @default.
- W2056397792 cites W2050705910 @default.
- W2056397792 cites W2057787621 @default.
- W2056397792 cites W2059180163 @default.
- W2056397792 cites W2060090253 @default.
- W2056397792 cites W2062332308 @default.
- W2056397792 cites W2066335559 @default.
- W2056397792 cites W2069472087 @default.
- W2056397792 cites W2070519593 @default.
- W2056397792 cites W2071278141 @default.
- W2056397792 cites W2074201173 @default.
- W2056397792 cites W2074615095 @default.
- W2056397792 cites W2075720172 @default.
- W2056397792 cites W2080046881 @default.
- W2056397792 cites W2080265450 @default.
- W2056397792 cites W2080930398 @default.
- W2056397792 cites W2084485648 @default.
- W2056397792 cites W2087354578 @default.
- W2056397792 cites W2091233344 @default.
- W2056397792 cites W2092294275 @default.
- W2056397792 cites W2093757762 @default.
- W2056397792 cites W2102035457 @default.
- W2056397792 cites W2102490794 @default.
- W2056397792 cites W2105024315 @default.
- W2056397792 cites W2140159910 @default.
- W2056397792 cites W2147773916 @default.
- W2056397792 cites W2160531011 @default.
- W2056397792 cites W2165798824 @default.
- W2056397792 cites W2171592578 @default.
- W2056397792 cites W2312364418 @default.
- W2056397792 cites W2336009356 @default.
- W2056397792 cites W2368879020 @default.
- W2056397792 doi "https://doi.org/10.1016/j.biopsych.2004.02.032" @default.
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