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• W2060089085 abstract "Primary hits that arise from screening one bead one compound (OBOC) libraries against a target of interest rarely have high potency. However, there has been little work focused on the development of an efficient workflow for primary hit improvement. In this study, we show that by characterizing the binding constants for all of the hits that arise from a screen, structure–activity relationship (SAR) data can be obtained to inform the design of “derivative libraries” of a primary hit that can then be screened under more demanding conditions to obtain improved compounds. Here, we demonstrate the rapid improvement of a primary hit against matrix metalloproteinase-14 using this approach." @default.
• W2060089085 created "2016-06-24" @default.
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• W2060089085 date "2014-12-19" @default.
• W2060089085 modified "2023-09-25" @default.
• W2060089085 title "Rapid Lead Discovery Through Iterative Screening of One Bead One Compound Libraries" @default.
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• W2060089085 doi "https://doi.org/10.1021/co500154e" @default.
• W2060089085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4294594" @default.
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