FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063436733> ?p ?o ?g. }

• W2063436733 endingPage "565" @default.
• W2063436733 startingPage "559" @default.
• W2063436733 abstract "Sedation is a common side effect of anticonvulsant drug therapy. To find out whether the new antiepileptic drugs, felbamate and lamotrigine, are able to produce sedation, we carried out electroencephalographic (EEG) studies in the rat to measure drug effects on sleep-wake patterns, during both light and dark phases. For comparison, the reference drugs, carbamazepine and phenobarbital, were also studied. EEG activity was recorded for 6 h after oral (PO) administration of drugs or vehicle, and the stages of wakefulness, rapid eye movements (REM) sleep and non-REM sleep were classified thereafter. In the light phase, felbamate (30-300 mg/kg) did not produce sedative effects, while lamotrigine (3-30 mg/kg) increased wakefulness at each dose tested. Carbamazepine (10-100 mg/kg) did not produce sleep-wake alterations, and phenobarbital (100 mg/kg) markedly suppressed REM. In the dark phase, felbamate (300 mg/kg), lamotrigine (30 mg/kg), and carbamazepine (100 mg/kg) reduced REM but did not change the total amount of sleep. Phenobarbital, at 100 mg/kg, markedly increased total sleep and greatly reduced REM. This study shows that the anticonvulsant drugs examined have different effects on the states of sleep and wakefulness in the rat. The data are discussed on the basis of the mechanism of action that characterizes each individual drug." @default.
• W2063436733 created "2016-06-24" @default.
• W2063436733 creator A5007995825 @default.
• W2063436733 creator A5032985349 @default.
• W2063436733 creator A5037632094 @default.
• W2063436733 creator A5051279237 @default.
• W2063436733 date "1996-03-01" @default.
• W2063436733 modified "2023-10-16" @default.
• W2063436733 title "Effects of four antiepileptic drugs on sleep and waking in the rat under both light and dark phases" @default.
• W2063436733 cites W1966862790 @default.
• W2063436733 cites W1969601640 @default.
• W2063436733 cites W1973639031 @default.
• W2063436733 cites W1975041404 @default.
• W2063436733 cites W1992469827 @default.
• W2063436733 cites W1997596070 @default.
• W2063436733 cites W1999374340 @default.
• W2063436733 cites W2005795855 @default.
• W2063436733 cites W2006586562 @default.
• W2063436733 cites W2010272426 @default.
• W2063436733 cites W2023281672 @default.
• W2063436733 cites W2024173492 @default.
• W2063436733 cites W2024462961 @default.
• W2063436733 cites W2026019430 @default.
• W2063436733 cites W2037132619 @default.
• W2063436733 cites W2037693876 @default.
• W2063436733 cites W2059917220 @default.
• W2063436733 cites W2072463642 @default.
• W2063436733 cites W2073515610 @default.
• W2063436733 cites W2077725893 @default.
• W2063436733 cites W2081555717 @default.
• W2063436733 cites W2086360825 @default.
• W2063436733 cites W2119093004 @default.
• W2063436733 cites W2138812583 @default.
• W2063436733 cites W2436871336 @default.
• W2063436733 cites W4234601803 @default.
• W2063436733 cites W4244479235 @default.
• W2063436733 doi "https://doi.org/10.1016/0091-3057(95)02050-0" @default.
• W2063436733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8866955" @default.
• W2063436733 hasPublicationYear "1996" @default.
• W2063436733 type Work @default.
• W2063436733 sameAs 2063436733 @default.
• W2063436733 citedByCount "13" @default.
• W2063436733 countsByYear W20634367332014 @default.
• W2063436733 crossrefType "journal-article" @default.
• W2063436733 hasAuthorship W2063436733A5007995825 @default.
• W2063436733 hasAuthorship W2063436733A5032985349 @default.
• W2063436733 hasAuthorship W2063436733A5037632094 @default.
• W2063436733 hasAuthorship W2063436733A5051279237 @default.
• W2063436733 hasConcept C111919701 @default.
• W2063436733 hasConcept C15744967 @default.
• W2063436733 hasConcept C169760540 @default.
• W2063436733 hasConcept C185592680 @default.
• W2063436733 hasConcept C2775841894 @default.
• W2063436733 hasConcept C2775858608 @default.
• W2063436733 hasConcept C2776175493 @default.
• W2063436733 hasConcept C2776814716 @default.
• W2063436733 hasConcept C2778186239 @default.
• W2063436733 hasConcept C2778793413 @default.
• W2063436733 hasConcept C2778802184 @default.
• W2063436733 hasConcept C2779253243 @default.
• W2063436733 hasConcept C2779320081 @default.
• W2063436733 hasConcept C2781011581 @default.
• W2063436733 hasConcept C41008148 @default.
• W2063436733 hasConcept C42219234 @default.
• W2063436733 hasConcept C522805319 @default.
• W2063436733 hasConcept C71924100 @default.
• W2063436733 hasConcept C98274493 @default.
• W2063436733 hasConceptScore W2063436733C111919701 @default.
• W2063436733 hasConceptScore W2063436733C15744967 @default.
• W2063436733 hasConceptScore W2063436733C169760540 @default.
• W2063436733 hasConceptScore W2063436733C185592680 @default.
• W2063436733 hasConceptScore W2063436733C2775841894 @default.
• W2063436733 hasConceptScore W2063436733C2775858608 @default.
• W2063436733 hasConceptScore W2063436733C2776175493 @default.
• W2063436733 hasConceptScore W2063436733C2776814716 @default.
• W2063436733 hasConceptScore W2063436733C2778186239 @default.
• W2063436733 hasConceptScore W2063436733C2778793413 @default.
• W2063436733 hasConceptScore W2063436733C2778802184 @default.
• W2063436733 hasConceptScore W2063436733C2779253243 @default.
• W2063436733 hasConceptScore W2063436733C2779320081 @default.
• W2063436733 hasConceptScore W2063436733C2781011581 @default.
• W2063436733 hasConceptScore W2063436733C41008148 @default.
• W2063436733 hasConceptScore W2063436733C42219234 @default.
• W2063436733 hasConceptScore W2063436733C522805319 @default.
• W2063436733 hasConceptScore W2063436733C71924100 @default.
• W2063436733 hasConceptScore W2063436733C98274493 @default.
• W2063436733 hasIssue "3" @default.
• W2063436733 hasLocation W20634367331 @default.
• W2063436733 hasLocation W20634367332 @default.
• W2063436733 hasOpenAccess W2063436733 @default.
• W2063436733 hasPrimaryLocation W20634367331 @default.
• W2063436733 hasRelatedWork W1992085593 @default.
• W2063436733 hasRelatedWork W2014906362 @default.
• W2063436733 hasRelatedWork W2042165149 @default.
• W2063436733 hasRelatedWork W2050287406 @default.
• W2063436733 hasRelatedWork W2057078791 @default.
• W2063436733 hasRelatedWork W2063436733 @default.
• W2063436733 hasRelatedWork W2075125615 @default.

• next