FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063701567> ?p ?o ?g. }

• W2063701567 endingPage "32" @default.
• W2063701567 startingPage "27" @default.
• W2063701567 abstract "Progesterone (P), its metabolites, and other neuroactive steroids alter pain thresholds consistent with their efficacies at modulating γ-aminobutyric acid (GABAA) receptor complexes. We investigated whether estradiol benzoate (EB) potentiates low dosages of neuroactive steroids' effects on pain. Subcutaneous EB (10 μg) or sesame oil vehicle was administered to ovariectomized Long-Evans rats (n = 40) 48 h before intracerebroventricular (ICV) infusion of a neuroactive steroid (0.0, 0.1, 0.3, or 0.5 μg) in cyclodextrin vehicle. Neuroactive steroids (listed from greatest to least efficacious at GABAA receptor complexes) were THP [5α-pregnan-3α-ol-20-one], THDOC [5α-pregnan-3α, 21-diol-20-one], DHP [5α-pregnan-3,20-dione], P [4-pregnen-3,20-dione], and DHEAS [5-androsten-3β-ol-17-one sulfate]. Pain sensitivity was assessed using the radiant heat tail-flick method before and 20 and 60 min following infusion. Estradiol benzoate interacted with the neuroactive steroids to alter tail-flick latencies. In particular, EB potentiated the antinociceptive effect of THP and DHP by significantly increasing tail-flick latencies above those of non-EB-treated animals. A similar pattern of increased tail-flick latencies occurred in EB-primed animals that received THDOC. Estradiol benzoate less consistently altered the pain threshold of animals administered P, which is less effective at modulating GABAergic activity. Conversely, EB increased the nociceptive effect of the neurosteroid DHEAS, an allosteric antagonist of GABAA receptor complexes, by significantly decreasing tail-flick latencies of EB- compared to vehicle-primed rats. Thus, EB priming potentiated neuroactive steroids' effects on pain threshold." @default.
• W2063701567 created "2016-06-24" @default.
• W2063701567 creator A5009051197 @default.
• W2063701567 creator A5019851140 @default.
• W2063701567 date "1996-01-01" @default.
• W2063701567 modified "2023-10-18" @default.
• W2063701567 title "Estradiol benzoate potentiates neuroactive steroids' effects on pain sensitivity" @default.
• W2063701567 cites W1945375049 @default.
• W2063701567 cites W1968001086 @default.
• W2063701567 cites W1970878531 @default.
• W2063701567 cites W1972888313 @default.
• W2063701567 cites W1974682801 @default.
• W2063701567 cites W1976747637 @default.
• W2063701567 cites W1977122237 @default.
• W2063701567 cites W1978357314 @default.
• W2063701567 cites W1981958557 @default.
• W2063701567 cites W1986191052 @default.
• W2063701567 cites W1996652788 @default.
• W2063701567 cites W2002618947 @default.
• W2063701567 cites W2002956999 @default.
• W2063701567 cites W2005825980 @default.
• W2063701567 cites W2008392190 @default.
• W2063701567 cites W2012618926 @default.
• W2063701567 cites W2012915393 @default.
• W2063701567 cites W2014370769 @default.
• W2063701567 cites W2016153132 @default.
• W2063701567 cites W2017336787 @default.
• W2063701567 cites W2017663786 @default.
• W2063701567 cites W2024344189 @default.
• W2063701567 cites W2024822444 @default.
• W2063701567 cites W2027645010 @default.
• W2063701567 cites W2028991485 @default.
• W2063701567 cites W2029172515 @default.
• W2063701567 cites W2037025019 @default.
• W2063701567 cites W2042459618 @default.
• W2063701567 cites W2044154535 @default.
• W2063701567 cites W2047114909 @default.
• W2063701567 cites W2048982634 @default.
• W2063701567 cites W2049633200 @default.
• W2063701567 cites W2060334160 @default.
• W2063701567 cites W2060838533 @default.
• W2063701567 cites W2064833080 @default.
• W2063701567 cites W2066739179 @default.
• W2063701567 cites W2067275030 @default.
• W2063701567 cites W2068380366 @default.
• W2063701567 cites W2069438724 @default.
• W2063701567 cites W2070006732 @default.
• W2063701567 cites W2071285357 @default.
• W2063701567 cites W2071517246 @default.
• W2063701567 cites W2073971076 @default.
• W2063701567 cites W2079698325 @default.
• W2063701567 cites W2080602367 @default.
• W2063701567 cites W2083447043 @default.
• W2063701567 cites W2084230118 @default.
• W2063701567 cites W2085408567 @default.
• W2063701567 cites W2086419158 @default.
• W2063701567 cites W2088794972 @default.
• W2063701567 cites W2090322671 @default.
• W2063701567 cites W2091834572 @default.
• W2063701567 cites W2092240974 @default.
• W2063701567 cites W2095997621 @default.
• W2063701567 cites W2118502261 @default.
• W2063701567 cites W2166131386 @default.
• W2063701567 cites W2176076159 @default.
• W2063701567 cites W2429425220 @default.
• W2063701567 cites W2468936323 @default.
• W2063701567 cites W428850520 @default.
• W2063701567 cites W954373710 @default.
• W2063701567 cites W628290439 @default.
• W2063701567 doi "https://doi.org/10.1016/0091-3057(95)00194-8" @default.
• W2063701567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8848456" @default.
• W2063701567 hasPublicationYear "1996" @default.
• W2063701567 type Work @default.
• W2063701567 sameAs 2063701567 @default.
• W2063701567 citedByCount "52" @default.
• W2063701567 countsByYear W20637015672013 @default.
• W2063701567 countsByYear W20637015672015 @default.
• W2063701567 countsByYear W20637015672020 @default.
• W2063701567 crossrefType "journal-article" @default.
• W2063701567 hasAuthorship W2063701567A5009051197 @default.
• W2063701567 hasAuthorship W2063701567A5019851140 @default.
• W2063701567 hasConcept C126322002 @default.
• W2063701567 hasConcept C134018914 @default.
• W2063701567 hasConcept C15490471 @default.
• W2063701567 hasConcept C168258287 @default.
• W2063701567 hasConcept C170493617 @default.
• W2063701567 hasConcept C185592680 @default.
• W2063701567 hasConcept C2776801781 @default.
• W2063701567 hasConcept C2777164284 @default.
• W2063701567 hasConcept C2778173252 @default.
• W2063701567 hasConcept C2778506572 @default.
• W2063701567 hasConcept C44796713 @default.
• W2063701567 hasConcept C52396799 @default.
• W2063701567 hasConcept C71924100 @default.
• W2063701567 hasConcept C8264082 @default.
• W2063701567 hasConcept C98274493 @default.
• W2063701567 hasConceptScore W2063701567C126322002 @default.
• W2063701567 hasConceptScore W2063701567C134018914 @default.

• next