FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064014274> ?p ?o ?g. }

• W2064014274 endingPage "140" @default.
• W2064014274 startingPage "133" @default.
• W2064014274 abstract "Oxidative stress and modulation of anti-oxidant enzymes may contribute to the deleterious consequences of diabetes mellitus and to the effects of chronic (i.e. 21 day) stress in the CNS. We therefore compared the effects of short- and long-term exposure to diabetes-induced hyperglycemia, restraint stress and the combined effects of restraint stress and diabetes upon parameters of oxidative stress in the rat hippocampus. Whereas 7 days of restraint stress or hyperglycemia, or the combination, produced similar increases in oxidative stress markers 4-hydroxy-2-nonenal (HNE) and malondialdehyde (MDA) throughout the hippocampus, 21 days of stress or hyperglycemia did not increase these markers in the dentate gyrus. In contrast, Ammon's horn still showed elevated levels of these lipid peroxidation products, especially in diabetic rats subjected to 21 days of restraint stress. The expression of two anti-oxidant enzymes, copper/zinc superoxide dismutase (Cu/Zn-SOD) and manganese SOD, was also differentially regulated by stress and hyperglycemia in a time- and region-specific manner in the rat hippocampus. Although long-term stress decreased both SOD isoforms, diabetes increased Cu/Zn-SOD expression in DG with or without 21 days of repeated stress. These increases may account for the finding that protein-conjugated HNE and MDA levels returned to control levels between 7 days and 21 days of hyperglycemia or the combination of diabetes and stress. These results suggest that while other anti-oxidant pathways may account for decreases in oxidative stress in the long-term stress paradigm, increases in Cu/Zn-SOD expression may contribute to the region-specific attenuation of oxidative stress in the diabetic rat hippocampus." @default.
• W2064014274 created "2016-06-24" @default.
• W2064014274 creator A5002858060 @default.
• W2064014274 creator A5016896047 @default.
• W2064014274 creator A5024651281 @default.
• W2064014274 creator A5033862279 @default.
• W2064014274 creator A5035103174 @default.
• W2064014274 creator A5077387187 @default.
• W2064014274 date "2003-09-01" @default.
• W2064014274 modified "2023-10-02" @default.
• W2064014274 title "Region specific increases in oxidative stress and superoxide dismutase in the hippocampus of diabetic rats subjected to stress" @default.
• W2064014274 cites W1536700299 @default.
• W2064014274 cites W1546743948 @default.
• W2064014274 cites W1550462067 @default.
• W2064014274 cites W1551985194 @default.
• W2064014274 cites W1642124290 @default.
• W2064014274 cites W1953115230 @default.
• W2064014274 cites W1968418355 @default.
• W2064014274 cites W1970261217 @default.
• W2064014274 cites W1975391137 @default.
• W2064014274 cites W1976380907 @default.
• W2064014274 cites W1981611094 @default.
• W2064014274 cites W1982092983 @default.
• W2064014274 cites W1994498285 @default.
• W2064014274 cites W2010585911 @default.
• W2064014274 cites W2012286557 @default.
• W2064014274 cites W2014369590 @default.
• W2064014274 cites W2014697941 @default.
• W2064014274 cites W2019153443 @default.
• W2064014274 cites W2024583667 @default.
• W2064014274 cites W2025863842 @default.
• W2064014274 cites W2029793355 @default.
• W2064014274 cites W2032948761 @default.
• W2064014274 cites W2034308170 @default.
• W2064014274 cites W2035615746 @default.
• W2064014274 cites W2036284058 @default.
• W2064014274 cites W2047298914 @default.
• W2064014274 cites W2047351833 @default.
• W2064014274 cites W2049192526 @default.
• W2064014274 cites W2049207423 @default.
• W2064014274 cites W2057658065 @default.
• W2064014274 cites W2075895715 @default.
• W2064014274 cites W2080002880 @default.
• W2064014274 cites W2081674053 @default.
• W2064014274 cites W2086961763 @default.
• W2064014274 cites W2091363346 @default.
• W2064014274 cites W2115337518 @default.
• W2064014274 cites W2116721266 @default.
• W2064014274 cites W2132335976 @default.
• W2064014274 cites W2135855823 @default.
• W2064014274 cites W2153690605 @default.
• W2064014274 cites W2164626680 @default.
• W2064014274 cites W2334787351 @default.
• W2064014274 cites W3010107599 @default.
• W2064014274 cites W4211227687 @default.
• W2064014274 cites W1987590315 @default.
• W2064014274 doi "https://doi.org/10.1016/s0306-4522(03)00343-9" @default.
• W2064014274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12946706" @default.
• W2064014274 hasPublicationYear "2003" @default.
• W2064014274 type Work @default.
• W2064014274 sameAs 2064014274 @default.
• W2064014274 citedByCount "65" @default.
• W2064014274 countsByYear W20640142742012 @default.
• W2064014274 countsByYear W20640142742013 @default.
• W2064014274 countsByYear W20640142742014 @default.
• W2064014274 countsByYear W20640142742015 @default.
• W2064014274 countsByYear W20640142742016 @default.
• W2064014274 countsByYear W20640142742017 @default.
• W2064014274 countsByYear W20640142742018 @default.
• W2064014274 countsByYear W20640142742020 @default.
• W2064014274 countsByYear W20640142742021 @default.
• W2064014274 countsByYear W20640142742022 @default.
• W2064014274 countsByYear W20640142742023 @default.
• W2064014274 crossrefType "journal-article" @default.
• W2064014274 hasAuthorship W2064014274A5002858060 @default.
• W2064014274 hasAuthorship W2064014274A5016896047 @default.
• W2064014274 hasAuthorship W2064014274A5024651281 @default.
• W2064014274 hasAuthorship W2064014274A5033862279 @default.
• W2064014274 hasAuthorship W2064014274A5035103174 @default.
• W2064014274 hasAuthorship W2064014274A5077387187 @default.
• W2064014274 hasConcept C126322002 @default.
• W2064014274 hasConcept C134018914 @default.
• W2064014274 hasConcept C185592680 @default.
• W2064014274 hasConcept C2775838275 @default.
• W2064014274 hasConcept C2776151105 @default.
• W2064014274 hasConcept C2776464000 @default.
• W2064014274 hasConcept C2778401633 @default.
• W2064014274 hasConcept C2780829032 @default.
• W2064014274 hasConcept C2781161787 @default.
• W2064014274 hasConcept C555293320 @default.
• W2064014274 hasConcept C71924100 @default.
• W2064014274 hasConceptScore W2064014274C126322002 @default.
• W2064014274 hasConceptScore W2064014274C134018914 @default.
• W2064014274 hasConceptScore W2064014274C185592680 @default.
• W2064014274 hasConceptScore W2064014274C2775838275 @default.
• W2064014274 hasConceptScore W2064014274C2776151105 @default.
• W2064014274 hasConceptScore W2064014274C2776464000 @default.
• W2064014274 hasConceptScore W2064014274C2778401633 @default.

• next