FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064037082> ?p ?o ?g. }

• W2064037082 endingPage "35" @default.
• W2064037082 startingPage "19" @default.
• W2064037082 abstract "In recent studies, we and others showed that autophagy is critical to estrogen receptor positive (ER+) breast cancer cell survival and the development of antiestrogen resistance. Consequently, new approaches are warranted for targeting autophagy in breast cancer cells undergoing antiestrogen therapy. Because crosstalk has been demonstrated between the autophagy- and proteasome-mediated pathways of protein degradation, this study investigated how the proteasome inhibitor bortezomib affects autophagy and cell survival in antiestrogen-treated ER+ breast cancer cells. Bortezomib, at clinically achievable doses, induced a robust death response in ER+, antiestrogen-sensitive and antiestrogen-resistant breast cancer cells undergoing hormonal therapy. Cleavage of PARP and lamin A was detectable as a read-out of cell death, following bortezomib-induced mitochondrial dysfunction. Prior to induction of cell death, bortezomib-treated cells showed high levels of light chain 3 (LC3) and p62, two protein markers for autophagy. The accumulation of these proteins was due to bortezomib-mediated blockade of long-lived protein turnover during macroautophagy. This novel action of bortezomib was linked to its blockade of cathepsin-L activity, which is required for autolysosomal-mediated protein turnover in ER+ breast cancer cells. Further, bortezomib-treated breast cancer cells showed induction of the unfolded protein response, with upregulation of CH OP and GRP78. Bortezomib also induced high levels of the pro-apoptotic protein BNIP3. Knockdown of CH OP and/or BNIP3 expression via RNAi targeting significantly attenuated the death-promoting effects of bortezomib. Thus, bortezomib inhibits prosurvival autophagy, in addition to its known function in blocking the proteasome, and is cytotoxic to hormonally treated ER+ breast cancer cells. These findings indicate that combining a proteasome inhibitor like bortezomib with antiestrogen therapy may have therapeutic advantage in the management of early-stage breast cancer." @default.
• W2064037082 created "2016-06-24" @default.
• W2064037082 creator A5014054125 @default.
• W2064037082 creator A5034508836 @default.
• W2064037082 creator A5041027224 @default.
• W2064037082 creator A5047037224 @default.
• W2064037082 creator A5063964193 @default.
• W2064037082 creator A5074949043 @default.
• W2064037082 creator A5076627279 @default.
• W2064037082 creator A5079069209 @default.
• W2064037082 creator A5081814024 @default.
• W2064037082 creator A5083254762 @default.
• W2064037082 creator A5091451352 @default.
• W2064037082 date "2010-01-01" @default.
• W2064037082 modified "2023-10-08" @default.
• W2064037082 title "Bortezomib blocks the catabolic process of autophagy via a cathepsin-dependent mechanism, affects endoplasmic reticulum stress, and induces caspase-dependent cell death in antiestrogen–sensitive and resistant ER+ breast cancer cells" @default.
• W2064037082 cites W1480445443 @default.
• W2064037082 cites W1487550568 @default.
• W2064037082 cites W1531964529 @default.
• W2064037082 cites W1550693054 @default.
• W2064037082 cites W170520254 @default.
• W2064037082 cites W1967939830 @default.
• W2064037082 cites W1972638371 @default.
• W2064037082 cites W1985139784 @default.
• W2064037082 cites W1985275612 @default.
• W2064037082 cites W1990138203 @default.
• W2064037082 cites W1998162919 @default.
• W2064037082 cites W2000940681 @default.
• W2064037082 cites W2005547107 @default.
• W2064037082 cites W2010708627 @default.
• W2064037082 cites W2012875419 @default.
• W2064037082 cites W2014918593 @default.
• W2064037082 cites W2026622074 @default.
• W2064037082 cites W2030042413 @default.
• W2064037082 cites W2039369023 @default.
• W2064037082 cites W2039522499 @default.
• W2064037082 cites W2052607700 @default.
• W2064037082 cites W2057518766 @default.
• W2064037082 cites W2060756680 @default.
• W2064037082 cites W2062886087 @default.
• W2064037082 cites W2070254246 @default.
• W2064037082 cites W2073131935 @default.
• W2064037082 cites W2074857405 @default.
• W2064037082 cites W2074911710 @default.
• W2064037082 cites W2079956632 @default.
• W2064037082 cites W2082796078 @default.
• W2064037082 cites W2087920955 @default.
• W2064037082 cites W2089198803 @default.
• W2064037082 cites W2090378553 @default.
• W2064037082 cites W2092875352 @default.
• W2064037082 cites W2097066287 @default.
• W2064037082 cites W2110680001 @default.
• W2064037082 cites W2111666727 @default.
• W2064037082 cites W2113492659 @default.
• W2064037082 cites W2114167623 @default.
• W2064037082 cites W2116380331 @default.
• W2064037082 cites W2121656289 @default.
• W2064037082 cites W2122476299 @default.
• W2064037082 cites W2123512383 @default.
• W2064037082 cites W2130325895 @default.
• W2064037082 cites W2135574023 @default.
• W2064037082 cites W2137662702 @default.
• W2064037082 cites W2146124002 @default.
• W2064037082 cites W2149896515 @default.
• W2064037082 cites W2150043714 @default.
• W2064037082 cites W2158535498 @default.
• W2064037082 cites W2163655381 @default.
• W2064037082 cites W2165241692 @default.
• W2064037082 cites W2409498254 @default.
• W2064037082 cites W2469635343 @default.
• W2064037082 cites W2950998817 @default.
• W2064037082 cites W75561624 @default.
• W2064037082 doi "https://doi.org/10.4161/auto.6.1.10323" @default.
• W2064037082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20110775" @default.
• W2064037082 hasPublicationYear "2010" @default.
• W2064037082 type Work @default.
• W2064037082 sameAs 2064037082 @default.
• W2064037082 citedByCount "62" @default.
• W2064037082 countsByYear W20640370822012 @default.
• W2064037082 countsByYear W20640370822013 @default.
• W2064037082 countsByYear W20640370822014 @default.
• W2064037082 countsByYear W20640370822015 @default.
• W2064037082 countsByYear W20640370822016 @default.
• W2064037082 countsByYear W20640370822017 @default.
• W2064037082 countsByYear W20640370822018 @default.
• W2064037082 countsByYear W20640370822019 @default.
• W2064037082 countsByYear W20640370822020 @default.
• W2064037082 countsByYear W20640370822021 @default.
• W2064037082 countsByYear W20640370822022 @default.
• W2064037082 countsByYear W20640370822023 @default.
• W2064037082 crossrefType "journal-article" @default.
• W2064037082 hasAuthorship W2064037082A5014054125 @default.
• W2064037082 hasAuthorship W2064037082A5034508836 @default.
• W2064037082 hasAuthorship W2064037082A5041027224 @default.
• W2064037082 hasAuthorship W2064037082A5047037224 @default.
• W2064037082 hasAuthorship W2064037082A5063964193 @default.
• W2064037082 hasAuthorship W2064037082A5074949043 @default.
• W2064037082 hasAuthorship W2064037082A5076627279 @default.

• next