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- W2066452988 abstract "Ligand discovery initiatives are facing interesting challenges as ever-increasing numbers of proteins are entering screening programs. As an answer to steady pressure to improve performance in drug discovery, ligand discovery can expect to play an expanded role in generating small molecules as probes to help uncover the function of novel proteins. Chromatographic assay formats can offer new entry points into standard interaction characterization (binding and rate constants) as well as powerful, scaleable methods for compound screening. This review presents recent advancements in chromatographic assay technology, with a particular focus on frontal affinity chromatography as a platform technology for interaction analysis." @default.
- W2066452988 created "2016-06-24" @default.
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- W2066452988 date "2005-12-01" @default.
- W2066452988 modified "2023-09-23" @default.
- W2066452988 title "Emerging challenges in ligand discovery: new opportunities for chromatographic assay" @default.
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- W2066452988 doi "https://doi.org/10.1586/14789450.2.6.891" @default.
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