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• W2068388603 abstract "The major mood disorders, which include bipolar disorder and major depressive disorder (MDD), are considered heritable traits, although previous genetic association studies have had limited success in robustly identifying risk loci. We performed a meta-analysis of five case-control cohorts for major mood disorder, including over 13,600 individuals genotyped on high-density SNP arrays. We identified SNPs at 3p21.1 associated with major mood disorders (rs2251219, P = 3.63 × 10−8; odds ratio = 0.87; 95% confidence interval, 0.83–0.92), with supportive evidence for association observed in two out of three independent replication cohorts. These results provide an example of a shared genetic susceptibility locus for bipolar disorder and MDD." @default.
• W2068388603 created "2016-06-24" @default.
• W2068388603 date "2010-01-17" @default.
• W2068388603 modified "2023-09-29" @default.
• W2068388603 title "Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1" @default.
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• W2068388603 doi "https://doi.org/10.1038/ng.523" @default.
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