Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069188859> ?p ?o ?g. }
- W2069188859 endingPage "366" @default.
- W2069188859 startingPage "354" @default.
- W2069188859 abstract "Purpose: For diseases with complex phenotype such as diabetic nephropathy (DN), integration of multiple Omics sources promises an improved description of the disease pathophysiology, being the basis for novel diagnostics and therapy, but equally important personalization aspects. Experimental design: Molecular features on DN were retrieved from public domain Omics studies and by mining scientific literature, patent text and clinical trial specifications. Molecular feature sets were consolidated on a human protein interaction network and interpreted on the level of molecular pathways in the light of the pathophysiology of the disease and its clinical context defined as associated biomarkers and drug targets. Results: About 1000 gene symbols each could be assigned to the pathophysiological description of DN and to the clinical context. Direct feature comparison showed minor overlap, whereas on the level of molecular pathways, the complement and coagulation cascade, PPAR signaling, and the renin–angiotensin system linked the disease descriptor space with biomarkers and targets. Conclusion and clinical relevance: Only the combined molecular feature landscapes closely reflect the clinical implications of DN in the context of hypertension and diabetes. Omics data integration on the level of interaction networks furthermore provides a platform for identification of pathway-specific biomarkers and therapy options." @default.
- W2069188859 created "2016-06-24" @default.
- W2069188859 creator A5004114465 @default.
- W2069188859 creator A5011970134 @default.
- W2069188859 creator A5019700420 @default.
- W2069188859 creator A5023641042 @default.
- W2069188859 creator A5051084819 @default.
- W2069188859 creator A5057262840 @default.
- W2069188859 creator A5059866150 @default.
- W2069188859 creator A5070359952 @default.
- W2069188859 creator A5077719225 @default.
- W2069188859 creator A5082866981 @default.
- W2069188859 creator A5083381431 @default.
- W2069188859 date "2011-04-14" @default.
- W2069188859 modified "2023-09-25" @default.
- W2069188859 title "Mapping of molecular pathways, biomarkers and drug targets for diabetic nephropathy" @default.
- W2069188859 cites W1901807044 @default.
- W2069188859 cites W1967490910 @default.
- W2069188859 cites W1972925702 @default.
- W2069188859 cites W1973090827 @default.
- W2069188859 cites W1980649172 @default.
- W2069188859 cites W1981637710 @default.
- W2069188859 cites W1981765976 @default.
- W2069188859 cites W1982092732 @default.
- W2069188859 cites W1982991932 @default.
- W2069188859 cites W1983539151 @default.
- W2069188859 cites W1984433875 @default.
- W2069188859 cites W1985941010 @default.
- W2069188859 cites W1987922761 @default.
- W2069188859 cites W1994887713 @default.
- W2069188859 cites W2000579954 @default.
- W2069188859 cites W2002599787 @default.
- W2069188859 cites W2009313526 @default.
- W2069188859 cites W2013656417 @default.
- W2069188859 cites W2020267609 @default.
- W2069188859 cites W2036209716 @default.
- W2069188859 cites W2041142934 @default.
- W2069188859 cites W2043102288 @default.
- W2069188859 cites W2043332056 @default.
- W2069188859 cites W2053385401 @default.
- W2069188859 cites W2054801022 @default.
- W2069188859 cites W2056116819 @default.
- W2069188859 cites W2058232119 @default.
- W2069188859 cites W2075897300 @default.
- W2069188859 cites W2077943216 @default.
- W2069188859 cites W2083045667 @default.
- W2069188859 cites W2093734025 @default.
- W2069188859 cites W2100409734 @default.
- W2069188859 cites W2100775121 @default.
- W2069188859 cites W2103237492 @default.
- W2069188859 cites W2104467180 @default.
- W2069188859 cites W2105130711 @default.
- W2069188859 cites W2108671185 @default.
- W2069188859 cites W2109876426 @default.
- W2069188859 cites W2110160785 @default.
- W2069188859 cites W2113181839 @default.
- W2069188859 cites W2117362890 @default.
- W2069188859 cites W2122202606 @default.
- W2069188859 cites W2130410032 @default.
- W2069188859 cites W2130965258 @default.
- W2069188859 cites W2133850955 @default.
- W2069188859 cites W2136145230 @default.
- W2069188859 cites W2136964217 @default.
- W2069188859 cites W2139634859 @default.
- W2069188859 cites W2141713511 @default.
- W2069188859 cites W2144164915 @default.
- W2069188859 cites W2147932812 @default.
- W2069188859 cites W2150818376 @default.
- W2069188859 cites W2151619278 @default.
- W2069188859 cites W2152415104 @default.
- W2069188859 cites W2155357669 @default.
- W2069188859 cites W2157117448 @default.
- W2069188859 cites W2161604082 @default.
- W2069188859 cites W2165019590 @default.
- W2069188859 cites W2170081060 @default.
- W2069188859 cites W2171294019 @default.
- W2069188859 cites W2340025308 @default.
- W2069188859 cites W2751771006 @default.
- W2069188859 doi "https://doi.org/10.1002/prca.201000136" @default.
- W2069188859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21491608" @default.
- W2069188859 hasPublicationYear "2011" @default.
- W2069188859 type Work @default.
- W2069188859 sameAs 2069188859 @default.
- W2069188859 citedByCount "36" @default.
- W2069188859 countsByYear W20691888592012 @default.
- W2069188859 countsByYear W20691888592013 @default.
- W2069188859 countsByYear W20691888592014 @default.
- W2069188859 countsByYear W20691888592015 @default.
- W2069188859 countsByYear W20691888592016 @default.
- W2069188859 countsByYear W20691888592017 @default.
- W2069188859 countsByYear W20691888592018 @default.
- W2069188859 countsByYear W20691888592019 @default.
- W2069188859 countsByYear W20691888592021 @default.
- W2069188859 countsByYear W20691888592022 @default.
- W2069188859 countsByYear W20691888592023 @default.
- W2069188859 crossrefType "journal-article" @default.
- W2069188859 hasAuthorship W2069188859A5004114465 @default.
- W2069188859 hasAuthorship W2069188859A5011970134 @default.