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• W2070603556 abstract "Diffuse gliomas are up till now graded based upon morphology. Recent findings indicate that isocitrate dehydrogenase (IDH) mutation status defines biologically distinct groups of tumors. The role of tumor grade and mitotic index in patient outcome has not been evaluated following stratification by IDH mutation status. To address this, we interrogated 558 WHO grade II–III diffuse gliomas for IDH1/2 mutations and investigated the prognostic impact of WHO grade within IDH-mutant and IDH-wild type tumor subsets independently. The prognostic impact of grade was modest in IDH-mutant [hazard ratio (HR) = 1.21, 95 % confidence interval (CI) = 0.91–1.61] compared to IDH-wild type tumors (HR = 1.74, 95 % CI = 0.95–3.16). Using a dichotomized mitotic index cut-off of 4/1000 tumor cells, we found that while mitotic index was significantly associated with outcome in IDH-wild type tumors (log-rank p < 0.0001, HR = 4.41, 95 % CI = 2.55–7.63), it was not associated with outcome in IDH-mutant tumors (log-rank p = 0.5157, HR = 1.10, 95 % CI = 0.80–1.51), and could demonstrate a statistical interaction (p < 0.0001) between IDH mutation and mitotic index (i.e., suggesting that the effect of mitotic index on patient outcome is dependent on IDH mutation status). Patient age, an established prognostic factor in diffuse glioma, was significantly associated with outcome only in the IDH-wild type subset, and consistent with prior data, 1p/19q co-deletion conferred improved outcome in the IDH-mutant cohort. These findings suggest that stratification of grade II–III gliomas into subsets defined by the presence or absence of IDH mutation leads to subgroups with distinct prognostic characteristics. Further evaluation of grading criteria and prognostic markers is warranted within IDH-mutant versus IDH-wild type diffuse grade II–III gliomas as independent entities." @default.
• W2070603556 created "2016-06-24" @default.
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• W2070603556 date "2015-02-21" @default.
• W2070603556 modified "2023-10-17" @default.
• W2070603556 title "IDH mutation status and role of WHO grade and mitotic index in overall survival in grade II–III diffuse gliomas" @default.
• W2070603556 cites W1530069278 @default.
• W2070603556 cites W1878193927 @default.
• W2070603556 cites W1921809757 @default.
• W2070603556 cites W1933395359 @default.
• W2070603556 cites W1964352665 @default.
• W2070603556 cites W1964609356 @default.
• W2070603556 cites W1979410391 @default.
• W2070603556 cites W1980656731 @default.
• W2070603556 cites W1985075740 @default.
• W2070603556 cites W1988756388 @default.
• W2070603556 cites W1995724633 @default.
• W2070603556 cites W1996908572 @default.
• W2070603556 cites W1997669802 @default.
• W2070603556 cites W1999831372 @default.
• W2070603556 cites W2001493754 @default.
• W2070603556 cites W2015102622 @default.
• W2070603556 cites W2015469768 @default.
• W2070603556 cites W2016770193 @default.
• W2070603556 cites W2017572322 @default.
• W2070603556 cites W2025183726 @default.
• W2070603556 cites W2036580114 @default.
• W2070603556 cites W2040827479 @default.
• W2070603556 cites W2041491651 @default.
• W2070603556 cites W2046029490 @default.
• W2070603556 cites W2046796218 @default.
• W2070603556 cites W2047474247 @default.
• W2070603556 cites W2048109276 @default.
• W2070603556 cites W2052681965 @default.
• W2070603556 cites W2066343654 @default.
• W2070603556 cites W2066825375 @default.
• W2070603556 cites W2079487111 @default.
• W2070603556 cites W2086945799 @default.
• W2070603556 cites W2088631065 @default.
• W2070603556 cites W2097483970 @default.
• W2070603556 cites W2100795816 @default.
• W2070603556 cites W2103672421 @default.
• W2070603556 cites W2104669585 @default.
• W2070603556 cites W2105348749 @default.
• W2070603556 cites W2105528101 @default.
• W2070603556 cites W2108392589 @default.
• W2070603556 cites W2109364195 @default.
• W2070603556 cites W2112495947 @default.
• W2070603556 cites W2112567075 @default.
• W2070603556 cites W2116232743 @default.
• W2070603556 cites W2116693415 @default.
• W2070603556 cites W2123151813 @default.
• W2070603556 cites W2126817554 @default.
• W2070603556 cites W2127901599 @default.
• W2070603556 cites W2129607979 @default.
• W2070603556 cites W2131117209 @default.
• W2070603556 cites W2131177535 @default.
• W2070603556 cites W2133865472 @default.
• W2070603556 cites W2134942438 @default.
• W2070603556 cites W2137013555 @default.
• W2070603556 cites W2138649599 @default.
• W2070603556 cites W2142630775 @default.
• W2070603556 cites W2146989265 @default.
• W2070603556 cites W2147013683 @default.
• W2070603556 cites W2149409455 @default.
• W2070603556 cites W2149840758 @default.
• W2070603556 cites W2151336775 @default.
• W2070603556 cites W2155677253 @default.
• W2070603556 cites W2158501128 @default.
• W2070603556 cites W2158565915 @default.
• W2070603556 cites W2159842626 @default.
• W2070603556 cites W2164338061 @default.
• W2070603556 cites W2164385994 @default.
• W2070603556 cites W2168383146 @default.
• W2070603556 cites W2171074831 @default.
• W2070603556 cites W2366536035 @default.
• W2070603556 cites W4205316981 @default.
• W2070603556 cites W4234177541 @default.
• W2070603556 cites W4376595439 @default.
• W2070603556 doi "https://doi.org/10.1007/s00401-015-1398-z" @default.
• W2070603556 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4369189" @default.
• W2070603556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25701198" @default.
• W2070603556 hasPublicationYear "2015" @default.
• W2070603556 type Work @default.

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