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- W2071915542 abstract "The aim of this article is to review current evidence-based approaches to treatment of ulcerative colitis and Crohn's disease.The primary goal of treatment is to induce and to maintain remission in a safe and efficacious fashion. The 5-aminosalicylic acid (5-ASA) agents and oral steroids remain the first-line approach for the treatment of ulcerative colitis and Crohn's disease. The 'step-up' approach includes the use of immunomodulators [azathioprine (AZA), or 6-mercaptopurine (6-MP)] and newer biologic agents (infliximab, adalimumab, and natalizumab). The 'step-down' approach can also be considered individually on the basis of the severity of Crohn's disease.Current treatment regimens still involve medications with well known efficacy and safety profiles and progress to more potent treatments such as immunomodulators and biologic agents. Adverse events of potent treatment with biologics and immunomodulators have been recognized. In some cases, aggressive approaches with the use of more potent agents as first-line therapy has been proposed, but they are still not considered a routine approach." @default.
- W2071915542 created "2016-06-24" @default.
- W2071915542 creator A5035191721 @default.
- W2071915542 creator A5044524314 @default.
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- W2071915542 date "2011-06-01" @default.
- W2071915542 modified "2023-09-28" @default.
- W2071915542 title "Inflammatory bowel disease therapy: current state-of-the-art" @default.
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- W2071915542 doi "https://doi.org/10.1097/mog.0b013e328347aef3" @default.
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