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• W2072318576 abstract "We report the synthesis, in vitro and in vivo investigation of folate-targeted, biocompatible, biodegradable self-assembled nanoparticles radiolabelled with 99mTc, as potential new SPECT or SPECT/CT imaging agent. Nanoparticles with hydrodynamic size in the range of 75–200 nm were prepared by self-assembly of chitosan and folated poly-γ-glutamic acid, and then radiolabelled with 99mTc. The nanoparticles target tumour cells overexpressing folate receptors and internalize specifically into them to realize early tumour diagnosis detected by SPECT and SPECT/CT modalities. Rat hepatocellular carcinoma cells were used as model system. Cell specificity and tumour targeting efficacy of these nanosystems were investigated in vitro, and in vivo using SPECT and fusion nanoSPECT/CT imaging. In vitro results showed that the radiolabeled nanosystem was efficiently internalized by tumour cells. Whole-body biodistribution of the new radiolabelled, folate-targeted nanoparticles revealed higher uptake in the tumorous kidney compared to the non-tumorous contralateral side. Uptake by the lungs and thyroids was negligible, which confirmed the stability of the nanoparticles in vivo. In vivo SPECT and SPECT/CT imaging visually reinforced the uptake results and were in accordance with the biodistribution data: the new nanoparticles as a targeted contrast agent improve tumour targeting and are able to detect folate-receptor-overexpressing tumours in animal models with enhanced contrast." @default.
• W2072318576 created "2016-06-24" @default.
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• W2072318576 date "2013-06-01" @default.
• W2072318576 modified "2023-10-17" @default.
• W2072318576 title "99mTc-labelled nanosystem as tumour imaging agent for SPECT and SPECT/CT modalities" @default.
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• W2072318576 doi "https://doi.org/10.1016/j.ijpharm.2013.03.049" @default.
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• W2072318576 hasPublicationYear "2013" @default.
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