Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072764312> ?p ?o ?g. }
- W2072764312 endingPage "3280" @default.
- W2072764312 startingPage "3275" @default.
- W2072764312 abstract "Viroids and most viral satellites have small, noncoding, and highly structured RNA genomes. How they cause disease symptoms without encoding proteins and why they have characteristic secondary structures are two longstanding questions. Recent studies have shown that both viroids and satellites are capable of inducing RNA silencing, suggesting a possible role of this mechanism in the pathology and evolution of these subviral RNAs. Here we show that preventing RNA silencing in tobacco, using a silencing suppressor, greatly reduces the symptoms caused by the Y satellite of cucumber mosaic virus. Furthermore, tomato plants expressing hairpin RNA, derived from potato spindle tuber viroid, developed symptoms similar to those of potato spindle tuber viroid infection. These results provide evidence suggesting that viroids and satellites cause disease symptoms by directing RNA silencing against physiologically important host genes. We also show that viroid and satellite RNAs are significantly resistant to RNA silencing-mediated degradation, suggesting that RNA silencing is an important selection pressure shaping the evolution of the secondary structures of these pathogens." @default.
- W2072764312 created "2016-06-24" @default.
- W2072764312 creator A5000886409 @default.
- W2072764312 creator A5026505344 @default.
- W2072764312 creator A5034535850 @default.
- W2072764312 creator A5043445752 @default.
- W2072764312 creator A5048355915 @default.
- W2072764312 creator A5050141240 @default.
- W2072764312 creator A5055855869 @default.
- W2072764312 creator A5060488268 @default.
- W2072764312 creator A5061069235 @default.
- W2072764312 creator A5062399275 @default.
- W2072764312 creator A5075047285 @default.
- W2072764312 creator A5079353531 @default.
- W2072764312 creator A5089285789 @default.
- W2072764312 date "2004-02-20" @default.
- W2072764312 modified "2023-10-14" @default.
- W2072764312 title "On the role of RNA silencing in the pathogenicity and evolution of viroids and viral satellites" @default.
- W2072764312 cites W1539503448 @default.
- W2072764312 cites W1589680365 @default.
- W2072764312 cites W1596438740 @default.
- W2072764312 cites W1856117416 @default.
- W2072764312 cites W1969322768 @default.
- W2072764312 cites W1974861468 @default.
- W2072764312 cites W1975050099 @default.
- W2072764312 cites W1979965542 @default.
- W2072764312 cites W2003520310 @default.
- W2072764312 cites W2006145675 @default.
- W2072764312 cites W2009326410 @default.
- W2072764312 cites W2021273278 @default.
- W2072764312 cites W2023457346 @default.
- W2072764312 cites W2028903821 @default.
- W2072764312 cites W2030489085 @default.
- W2072764312 cites W2037002709 @default.
- W2072764312 cites W2041222359 @default.
- W2072764312 cites W2047443513 @default.
- W2072764312 cites W2051144618 @default.
- W2072764312 cites W2054371299 @default.
- W2072764312 cites W2070792578 @default.
- W2072764312 cites W2077353367 @default.
- W2072764312 cites W2086593737 @default.
- W2072764312 cites W2094066651 @default.
- W2072764312 cites W2095300027 @default.
- W2072764312 cites W2109567740 @default.
- W2072764312 cites W2114165797 @default.
- W2072764312 cites W2118311078 @default.
- W2072764312 cites W2123985951 @default.
- W2072764312 cites W2125547495 @default.
- W2072764312 cites W2128946743 @default.
- W2072764312 cites W2135970805 @default.
- W2072764312 cites W2137794992 @default.
- W2072764312 cites W2140415861 @default.
- W2072764312 cites W2151355542 @default.
- W2072764312 cites W2155396586 @default.
- W2072764312 cites W2155985666 @default.
- W2072764312 cites W2158714788 @default.
- W2072764312 cites W2159190071 @default.
- W2072764312 cites W2166939217 @default.
- W2072764312 cites W2170237853 @default.
- W2072764312 cites W2317297187 @default.
- W2072764312 cites W2383233966 @default.
- W2072764312 cites W2474150060 @default.
- W2072764312 cites W75394086 @default.
- W2072764312 doi "https://doi.org/10.1073/pnas.0400104101" @default.
- W2072764312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/365780" @default.
- W2072764312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14978267" @default.
- W2072764312 hasPublicationYear "2004" @default.
- W2072764312 type Work @default.
- W2072764312 sameAs 2072764312 @default.
- W2072764312 citedByCount "273" @default.
- W2072764312 countsByYear W20727643122012 @default.
- W2072764312 countsByYear W20727643122013 @default.
- W2072764312 countsByYear W20727643122014 @default.
- W2072764312 countsByYear W20727643122015 @default.
- W2072764312 countsByYear W20727643122016 @default.
- W2072764312 countsByYear W20727643122017 @default.
- W2072764312 countsByYear W20727643122018 @default.
- W2072764312 countsByYear W20727643122019 @default.
- W2072764312 countsByYear W20727643122020 @default.
- W2072764312 countsByYear W20727643122021 @default.
- W2072764312 countsByYear W20727643122022 @default.
- W2072764312 countsByYear W20727643122023 @default.
- W2072764312 crossrefType "journal-article" @default.
- W2072764312 hasAuthorship W2072764312A5000886409 @default.
- W2072764312 hasAuthorship W2072764312A5026505344 @default.
- W2072764312 hasAuthorship W2072764312A5034535850 @default.
- W2072764312 hasAuthorship W2072764312A5043445752 @default.
- W2072764312 hasAuthorship W2072764312A5048355915 @default.
- W2072764312 hasAuthorship W2072764312A5050141240 @default.
- W2072764312 hasAuthorship W2072764312A5055855869 @default.
- W2072764312 hasAuthorship W2072764312A5060488268 @default.
- W2072764312 hasAuthorship W2072764312A5061069235 @default.
- W2072764312 hasAuthorship W2072764312A5062399275 @default.
- W2072764312 hasAuthorship W2072764312A5075047285 @default.
- W2072764312 hasAuthorship W2072764312A5079353531 @default.
- W2072764312 hasAuthorship W2072764312A5089285789 @default.
- W2072764312 hasBestOaLocation W20727643121 @default.
- W2072764312 hasConcept C104317684 @default.