FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072905764> ?p ?o ?g. }

• W2072905764 endingPage "283" @default.
• W2072905764 startingPage "277" @default.
• W2072905764 abstract "The effects of BPs on bone formation during mechanical loading are still unknown. In this study, we evaluated the effect of minodronate on the cortical bone response to mechanical loading applied using a 4-point bending device. We used six-month old female Wistar rats and randomized into five groups (N=10/group): Vehicle administration (VEH), low dose minodronate administration (MIN-L, 0.01 mg/kg BW), middle dose minodronate administration (MIN-M, 0.1mg/kg BW), high-dose minodronate administration (MIN-H 1mg/kg BW), and very high-dose minodronate administration (MIN-VH, 10mg/kg BW). Minodronate or vehicle was administered orally using the feeding needle at a dosage 3 times/week for 3 weeks. Loads on the right tibia at 38 N for 36 cycles at 2 Hz were applied in vivo by 4-point bending on the same day for 3 weeks. After calcein double labeling the rats were sacrificed and tibial cross sections were prepared from the region with maximal bending at the central diaphysis. Histomorphometry was performed at the entire periosteal and endocortical surface of the tibiae, dividing the periosteum into lateral and medial surfaces. The formation surface was reduced significantly in MIN-H and MIN-VH groups at the medial surface, and in MIN-VH group at the endocortical surface of the loaded tibia (p<0.01 vs. VEH). The mineral appositional rate was reduced significantly in MIN-H and MIN-VH groups at the endocortical surface of the loaded tibia (p<0.01 vs. VEH). The bone formation rate was significantly reduced in MIN-H group at the medial surface, and in MIN-H and MIN-VH groups at the endocortical surface of the loaded tibia (p<0.01 vs. VEH). However, no significant differences were observed in any parameters between the VEH group and either the MIN-L or MIN-M groups for both the loaded and non-loaded tibiae. Based on previous preventive studies in OVX rats, the optimal dose of minodronate for the treatment of osteoporosis would be 0.03 mg/kg (0.21 mg/kg/week). Therefore, we used 0.1mg/kg of minodronate 3 times/week (0.30 mg/kg/week) that was close to 0.21 mg/kg/week. In conclusion, minodronate does not reduce the cortical bone response to mechanical loading at the optimal dose for the treatment of osteoporosis in rat model." @default.
• W2072905764 created "2016-06-24" @default.
• W2072905764 creator A5009694708 @default.
• W2072905764 creator A5025363249 @default.
• W2072905764 creator A5064530411 @default.
• W2072905764 creator A5079002553 @default.
• W2072905764 date "2013-03-01" @default.
• W2072905764 modified "2023-09-23" @default.
• W2072905764 title "Effects of minodronate on cortical bone response to mechanical loading in rats" @default.
• W2072905764 cites W1968618281 @default.
• W2072905764 cites W1971689675 @default.
• W2072905764 cites W1975107690 @default.
• W2072905764 cites W1976894008 @default.
• W2072905764 cites W1979668257 @default.
• W2072905764 cites W1991817841 @default.
• W2072905764 cites W1993035292 @default.
• W2072905764 cites W2012719787 @default.
• W2072905764 cites W2017267215 @default.
• W2072905764 cites W2020056291 @default.
• W2072905764 cites W2027248329 @default.
• W2072905764 cites W2044402596 @default.
• W2072905764 cites W2050924816 @default.
• W2072905764 cites W2051917629 @default.
• W2072905764 cites W2061447013 @default.
• W2072905764 cites W2065232646 @default.
• W2072905764 cites W2071257673 @default.
• W2072905764 cites W2076107807 @default.
• W2072905764 cites W2076305352 @default.
• W2072905764 cites W2080787146 @default.
• W2072905764 cites W2080843536 @default.
• W2072905764 cites W2081071444 @default.
• W2072905764 cites W2084579646 @default.
• W2072905764 cites W2087378917 @default.
• W2072905764 cites W2088410873 @default.
• W2072905764 cites W2095704013 @default.
• W2072905764 cites W2098761213 @default.
• W2072905764 cites W2099054178 @default.
• W2072905764 cites W2102013349 @default.
• W2072905764 cites W2108958155 @default.
• W2072905764 cites W2109905589 @default.
• W2072905764 cites W2109938155 @default.
• W2072905764 cites W2121152609 @default.
• W2072905764 cites W2122711688 @default.
• W2072905764 cites W2124527463 @default.
• W2072905764 cites W2144453061 @default.
• W2072905764 cites W2144979351 @default.
• W2072905764 cites W2151942524 @default.
• W2072905764 cites W2153009489 @default.
• W2072905764 cites W2153446794 @default.
• W2072905764 cites W2161690532 @default.
• W2072905764 cites W2168264682 @default.
• W2072905764 cites W2170680219 @default.
• W2072905764 cites W2171221000 @default.
• W2072905764 doi "https://doi.org/10.1016/j.bone.2012.11.026" @default.
• W2072905764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23207800" @default.
• W2072905764 hasPublicationYear "2013" @default.
• W2072905764 type Work @default.
• W2072905764 sameAs 2072905764 @default.
• W2072905764 citedByCount "7" @default.
• W2072905764 countsByYear W20729057642015 @default.
• W2072905764 countsByYear W20729057642016 @default.
• W2072905764 countsByYear W20729057642017 @default.
• W2072905764 countsByYear W20729057642018 @default.
• W2072905764 crossrefType "journal-article" @default.
• W2072905764 hasAuthorship W2072905764A5009694708 @default.
• W2072905764 hasAuthorship W2072905764A5025363249 @default.
• W2072905764 hasAuthorship W2072905764A5064530411 @default.
• W2072905764 hasAuthorship W2072905764A5079002553 @default.
• W2072905764 hasBestOaLocation W20729057642 @default.
• W2072905764 hasConcept C105702510 @default.
• W2072905764 hasConcept C117866178 @default.
• W2072905764 hasConcept C126322002 @default.
• W2072905764 hasConcept C141071460 @default.
• W2072905764 hasConcept C185592680 @default.
• W2072905764 hasConcept C2776541429 @default.
• W2072905764 hasConcept C2776872141 @default.
• W2072905764 hasConcept C2777236700 @default.
• W2072905764 hasConcept C2777674748 @default.
• W2072905764 hasConcept C2778951355 @default.
• W2072905764 hasConcept C2780554211 @default.
• W2072905764 hasConcept C2781451080 @default.
• W2072905764 hasConcept C2909674915 @default.
• W2072905764 hasConcept C2993291840 @default.
• W2072905764 hasConcept C3018268312 @default.
• W2072905764 hasConcept C41625074 @default.
• W2072905764 hasConcept C55493867 @default.
• W2072905764 hasConcept C71924100 @default.
• W2072905764 hasConcept C8337478 @default.
• W2072905764 hasConceptScore W2072905764C105702510 @default.
• W2072905764 hasConceptScore W2072905764C117866178 @default.
• W2072905764 hasConceptScore W2072905764C126322002 @default.
• W2072905764 hasConceptScore W2072905764C141071460 @default.
• W2072905764 hasConceptScore W2072905764C185592680 @default.
• W2072905764 hasConceptScore W2072905764C2776541429 @default.
• W2072905764 hasConceptScore W2072905764C2776872141 @default.
• W2072905764 hasConceptScore W2072905764C2777236700 @default.
• W2072905764 hasConceptScore W2072905764C2777674748 @default.
• W2072905764 hasConceptScore W2072905764C2778951355 @default.

• next