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• W2073160738 endingPage "5585" @default.
• W2073160738 startingPage "5580" @default.
• W2073160738 abstract "The toxicological effects of perfluoroalkyl acids on the p-glycoprotein (p-gp) cellular efflux transporter were investigated using the marine mussel Mytilus californianus as a model system. Four of the perfluoroalkyl acids studied exhibit chemosensitizing behavior, significantly inhibiting p-gp transporter activity. The inhibitory potency is maximal for the longer chain acids perfluorononanoate (PFNA) and perfluorodecanoate (PFDA), with average IC50 values of 4.8 and 7.1 μM, respectively. Results indicate that PFNA inhibits p-gp by an indirect mechanism, and this inhibition is reversible and accompanied by a rapid loss of PFNA from the tissue. In addition, PFNA induces expression of the p-gp transporter after a 2-h exposure, a stress response that may result in a metabolic cost to the organism. Given that most organisms, including humans, share efflux transporters as a first line of defense against toxicants, the results of this study may have broader implications for the ecotoxicology of perfluoroalkyl acids." @default.
• W2073160738 created "2016-06-24" @default.
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• W2073160738 date "2006-07-28" @default.
• W2073160738 modified "2023-09-27" @default.
• W2073160738 title "New Perspectives on Perfluorochemical Ecotoxicology: Inhibition and Induction of an Efflux Transporter in the Marine Mussel, <i>Mytilus californianus</i>" @default.
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• W2073160738 doi "https://doi.org/10.1021/es0602593" @default.
• W2073160738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16999143" @default.
• W2073160738 hasPublicationYear "2006" @default.
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